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Gisadenafil besylate

Name: Gisadenafil besylate
Brand: TargetMol
SKU: T11400
Price: 148 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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Catalog No. T11400Cas No. 334827-98-4

Alias UK 369003-26

Gisadenafil besylate (UK 369003-26) is a specific, orally active phosphodiesterase 5 (PDE5) inhibitor that prevents the degradation of cyclic guanosine monophosphate (cGMP) with an IC50 of 3.6 nM.

Gisadenafil besylate

😃Good

Catalog No. T11400Alias UK 369003-26Cas No. 334827-98-4

Gisadenafil besylate (UK 369003-26) is a specific, orally active phosphodiesterase 5 (PDE5) inhibitor that prevents the degradation of cyclic guanosine monophosphate (cGMP) with an IC50 of 3.6 nM.

Pack Size	Price	Availability
25 mg	$683	8-10 weeks
50 mg	$888	8-10 weeks
100 mg	$1,340	8-10 weeks

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Product Introduction

Bioactivity

Description	Gisadenafil besylate (UK 369003-26) is a specific, orally active phosphodiesterase 5 (PDE5) inhibitor that prevents the degradation of cyclic guanosine monophosphate (cGMP) with an IC50 of 3.6 nM.
Targets&IC50	PDE1A:9.1 μM, PDE5A:3.6 nM
In vitro	The IC50 of Gisadenafil for PDE5A is 3.6 nM. In contrast, the IC50 of Gisadenafil for PDE1A is 9.1 μM, an approximately 2500-fold difference in specificity.Since some PDE5 inhibitors can also interact with PDE1 isotypes found within the cerebral vasculature, the specificity of Gisadenafil for PDE5 is confirmed.?This is directly tested with recombinant PDE5A and PDE1A overexpressed in COS-7 cells.
In vivo	Gisadenafil also restores the dilation of small (<25 μm) arterioles following hypercapnia, although it fails to restore full dilation of larger (>25 μm) vessels.
Alias	UK 369003-26

Chemical Properties

Molecular Weight	677.79
Formula	C₂₉H₃₉N₇O₈S₂
Cas No.	334827-98-4
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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Gisadenafil besylate