Shopping Cart

Remove All

Your shopping cart is currently empty

Gisadenafil

Select Batch

Purity:99.06%

Resource Download

COA LCMS HPLC HNMR

Gisadenafil

Catalog No. T15381Cas No. 334826-98-1

Gisadenafil (UK-369003) is a selective inhibitor of phosphodiesterase 5 (PDE5) with an IC50 of 3.6 nM and prevents degradation of cGMP.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
1 mg	$195	In Stock
5 mg	$437	In Stock
10 mg	$646	In Stock
25 mg	$987	In Stock
50 mg	$1,380	In Stock
100 mg	$1,860	In Stock
1 mL x 10 mM (in DMSO)	$547	In Stock

Bulk & Custom

Add to Cart

Questions

Related Compound Libraries of "Gisadenafil"

Product Introduction

Bioactivity

Description	Gisadenafil (UK-369003) is a selective inhibitor of phosphodiesterase 5 (PDE5) with an IC50 of 3.6 nM and prevents degradation of cGMP.
In vitro	In COS-7 cells, the IC50 of Gisadenafil for PDE1A is 9.1 μM, an approximately 2500-fold difference in selectivity[2].
In vivo	In male Tat-transgenic mice, Gisadenafil (2 mg/kg; i.p.) restores the dilation of small (<25 μm) arterioles following hypercapnia, although it fails to restore full dilation of larger (>25 μm) vessels. Gisadenafil largely restores the normal increase in cortical flow following hypercapnia in Tat-tg mice (17.5% above baseline)[2].
Alias	UK-369003

Chemical Properties

Molecular Weight	519.62
Formula	C23H33N7O5S
Cas No.	334826-98-1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (105.85 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9245 mL	9.6224 mL	19.2448 mL	96.2242 mL
5 mM	0.3849 mL	1.9245 mL	3.8490 mL	19.2448 mL
10 mM	0.1924 mL	0.9622 mL	1.9245 mL	9.6224 mL
20 mM	0.0962 mL	0.4811 mL	0.9622 mL	4.8112 mL
50 mM	0.0385 mL	0.1924 mL	0.3849 mL	1.9245 mL
100 mM	0.0192 mL	0.0962 mL	0.1924 mL	0.9622 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc