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GLUT4-IN-2

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Catalog No. T61695Cas No. 2454113-83-6

GLUT4-IN-2 is a specific GLUT4 inhibitor that inhibits GLUT1 and GLUT4.GLUT4-IN-2 has antitumor activity, induces apoptosis and cell cycle arrest, and can be used for cancer research.

GLUT4-IN-2

GLUT4-IN-2

😃Good
Purity: 99.90%
Catalog No. T61695Cas No. 2454113-83-6
GLUT4-IN-2 is a specific GLUT4 inhibitor that inhibits GLUT1 and GLUT4.GLUT4-IN-2 has antitumor activity, induces apoptosis and cell cycle arrest, and can be used for cancer research.
Pack SizePriceAvailabilityQuantity
50 mg$7896-8 weeks
100 mg$1,2806-8 weeks
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Purity:99.90%
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Product Introduction

Bioactivity
Description
GLUT4-IN-2 is a specific GLUT4 inhibitor that inhibits GLUT1 and GLUT4.GLUT4-IN-2 has antitumor activity, induces apoptosis and cell cycle arrest, and can be used for cancer research.
Targets&IC50
KCL-22:15.3 µM (CC50), CME:1.7 µM, K562:91.9 µM (CC50), HS-27:44.0 µM (CC50), GLUT4:6.8 μM, GLUT1:11.4 μM, MDA-MB-231 cells:45.1 µM (CC50)
In vitro
In CME, K562, KCL-22, MB-231, and HS-27 cells, GLUT4-IN-2 (1-100 µM; 48 hours) exhibited potent cytotoxicity, with cytotoxic concentration 50% (CC50) values of 1.7, 91.9, 15.3, 45.1, and 44.0 µM for CME, K562, KCL-22, MB-231, and HS-27 cells, respectively[1].
In vivo
In 8-10 week old SCID mice (CEM xenograft tumor model), GLUT4-IN-2 (50 mg/kg; i.p.; administered on days 1-5, 8-12, 15-18) showed potent antitumor activity in vivo[1].
Chemical Properties
Molecular Weight385.42
FormulaC17H11N3O4S2
Cas No.2454113-83-6
SmilesO=C1SC(=CC=2OC=CC2)C(=O)N1CC(=O)NC3=NC=4C=CC=CC4S3
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 80 mg/mL (207.57 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.5946 mL12.9729 mL25.9457 mL129.7286 mL
5 mM0.5189 mL2.5946 mL5.1891 mL25.9457 mL
10 mM0.2595 mL1.2973 mL2.5946 mL12.9729 mL
20 mM0.1297 mL0.6486 mL1.2973 mL6.4864 mL
50 mM0.0519 mL0.2595 mL0.5189 mL2.5946 mL
100 mM0.0259 mL0.1297 mL0.2595 mL1.2973 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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