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GLUT4-IN-2 is a specific GLUT4 inhibitor that inhibits GLUT1 and GLUT4.GLUT4-IN-2 has antitumor activity, induces apoptosis and cell cycle arrest, and can be used for cancer research.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
50 mg | $789 | 6-8 weeks | |
100 mg | $1,280 | 6-8 weeks |
Description | GLUT4-IN-2 is a specific GLUT4 inhibitor that inhibits GLUT1 and GLUT4.GLUT4-IN-2 has antitumor activity, induces apoptosis and cell cycle arrest, and can be used for cancer research. |
Targets&IC50 | KCL-22:15.3 µM (CC50), CME:1.7 µM, K562:91.9 µM (CC50), HS-27:44.0 µM (CC50), GLUT4:6.8 μM, GLUT1:11.4 μM, MDA-MB-231 cells:45.1 µM (CC50) |
In vitro | In CME, K562, KCL-22, MB-231, and HS-27 cells, GLUT4-IN-2 (1-100 µM; 48 hours) exhibited potent cytotoxicity, with cytotoxic concentration 50% (CC50) values of 1.7, 91.9, 15.3, 45.1, and 44.0 µM for CME, K562, KCL-22, MB-231, and HS-27 cells, respectively[1]. |
In vivo | In 8-10 week old SCID mice (CEM xenograft tumor model), GLUT4-IN-2 (50 mg/kg; i.p.; administered on days 1-5, 8-12, 15-18) showed potent antitumor activity in vivo[1]. |
Molecular Weight | 385.42 |
Formula | C17H11N3O4S2 |
Cas No. | 2454113-83-6 |
Smiles | O=C1SC(=CC=2OC=CC2)C(=O)N1CC(=O)NC3=NC=4C=CC=CC4S3 |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 80 mg/mL (207.57 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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