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GLUT inhibitor-1

GLUT inhibitor-1
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GLUT inhibitor-1

Catalog No. T40083Cas No. 2421141-40-2
GLUT inhibitor-1 is an orally active GLUT inhibitor with IC50 s of 242 nM and 179 nM for GLUT1 and GLUT3. GLUT inhibitor-1 can be used in studies about cancers and autoimmune diseases.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
5 mg$648Backorder
10 mg$997Backorder
25 mg$1,990Backorder
100 mgInquiryBackorder
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Product Introduction

Bioactivity
Description
GLUT inhibitor-1 is an orally active GLUT inhibitor with IC50 s of 242 nM and 179 nM for GLUT1 and GLUT3. GLUT inhibitor-1 can be used in studies about cancers and autoimmune diseases.
Targets&IC50
GLUT1:242 nM (IC50), GLUT3:179 nM (IC50)
In vivo
GLUT inhibitor-1 exhibits good oral pharmacokinetic parameters in mice and rats with oral Cmax values of 2525 and 1675 ng/mL, AUCs of 5890 and 6813 ng/mL, CLs of 40 and 37 mL/min/kg, Vdss of 1.70 and 4.51 L/Kg, t1/2s of 0.785 and 2.59h and Fs of 45.4% and 49.4%[1].
Chemical Properties
Molecular Weight549.67
FormulaC32H35N7O2
Cas No.2421141-40-2
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 90 mg/mL (163.7 mM), Sonication and heating to 60℃ are recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.8193 mL9.0964 mL18.1927 mL90.9637 mL
5 mM0.3639 mL1.8193 mL3.6385 mL18.1927 mL
10 mM0.1819 mL0.9096 mL1.8193 mL9.0964 mL
20 mM0.0910 mL0.4548 mL0.9096 mL4.5482 mL
50 mM0.0364 mL0.1819 mL0.3639 mL1.8193 mL
100 mM0.0182 mL0.0910 mL0.1819 mL0.9096 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
1 Enter information below:
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2 Enter the in vivo formulation:
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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