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GLUT inhibitor-1
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Catalog No. T40083Cas No. 2421141-40-2
GLUT inhibitor-1 is an orally active GLUT inhibitor with IC50 s of 242 nM and 179 nM for GLUT1 and GLUT3. GLUT inhibitor-1 can be used in studies about cancers and autoimmune diseases.
GLUT inhibitor-1
😃Good
Catalog No. T40083Cas No. 2421141-40-2
GLUT inhibitor-1 is an orally active GLUT inhibitor with IC50 s of 242 nM and 179 nM for GLUT1 and GLUT3. GLUT inhibitor-1 can be used in studies about cancers and autoimmune diseases.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $648 | Backorder | |
| 10 mg | $997 | Backorder | |
| 25 mg | $1,990 | Backorder | |
| 100 mg | Inquiry | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | GLUT inhibitor-1 is an orally active GLUT inhibitor with IC50 s of 242 nM and 179 nM for GLUT1 and GLUT3. GLUT inhibitor-1 can be used in studies about cancers and autoimmune diseases. |
| Targets&IC50 | GLUT3:179 nM (IC50), GLUT1:242 nM (IC50) |
| In vivo | GLUT inhibitor-1 exhibits good oral pharmacokinetic parameters in mice and rats with oral Cmax values of 2525 and 1675 ng/mL, AUCs of 5890 and 6813 ng/mL, CLs of 40 and 37 mL/min/kg, Vdss of 1.70 and 4.51 L/Kg, t1/2s of 0.785 and 2.59h and Fs of 45.4% and 49.4%[1]. |
| Molecular Weight | 549.67 |
| Formula | C32H35N7O2 |
| Cas No. | 2421141-40-2 |
| Smiles | CC1(CC1)NC(=O)COc1cccc(c1)-c1nc2CCN(Cc2c(Nc2ccc(cc2)-c2cn[nH]c2)n1)C1CCC1 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 90 mg/mL (163.7 mM), Sonication and heating to 60℃ are recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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