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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $56 | In Stock | |
1 mL x 10 mM (in DMSO) | $94 | In Stock |
Description | GSK3368715 dihydrochloride (EPZ019997 dihydrochloride) is an orally active and potent inhibitor of type I protein arginine methyltransferases (PRMTs) with anticancer and antitumor activity, inhibiting PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8, and can be used to study advanced solid tumors. |
In vitro | In the majority of 249 cancer cell lines representing 12 tumor types, GSK3368715 dihydrochloride (EPZ019997 dihydrochloride) exhibits 50% or more growth inhibition relative to DMSO-treated cells[1]. |
In vivo | GSK3368715 dihydrochloride (EPZ019997 dihydrochloride) significantly affects the growth of BxPC3 xenografts at all doses tested. In the 150- and 300-mg/kg dose groups, it reduces tumor growth by 78% and 97%, respectively[1]. |
Alias | EPZ019997 dihydrochloride, GSK3368715 2HCl, EPZ019997 2HCl |
Molecular Weight | 439.46 |
Formula | C20H40Cl2N4O2 |
Cas No. | 1628925-77-8 |
Storage | store at low temperature,store under nitrogen Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | H2O: 100 mg/mL (227.55 mM) DMSO: 100 mg/mL (227.55 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
H2O
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