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IMC-2C5
🥰Excellent
Catalog No. T9901A-227
Alias IMC2C5, Anti-PDGFRB/CD140b Antibody
IMC-2C5 is a humanized monoclonal antibody targeting PDGFRB/CD140b.
IMC-2C5
IMC-2C5
🥰Excellent
Catalog No. T9901A-227Alias IMC2C5, Anti-PDGFRB/CD140b Antibody
IMC-2C5 is a humanized monoclonal antibody targeting PDGFRB/CD140b.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $447 | In Stock | |
| 5 mg | $1,400 | In Stock | |
| 10 mg | $2,240 | In Stock | |
| 25 mg | $4,210 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | IMC-2C5 is a humanized monoclonal antibody targeting PDGFRB/CD140b. |
| Targets&IC50 | PDGFRβ (Ms):0.35 nM, PDGFRβ (human):0.55 nM |
| In vitro | The binding affinity of IMC-2C5 to hPDGFRβ and mPDGFRβ was 0.014 and 0.061 nM, respectively. IMC-2C5 inhibited the binding of hPDGFRβ to its ligand PDGF-B with an IC50 of 0.55 nM, while blocking the binding of mPDGFRβ to PDGF-B showed an IC50 of 0.35 nM. IMC-2C5 significantly inhibited the cell migration of PDGF-B (30 ng/ml) -stimulated NCI-H460, OVCAR-8, WS-1, and U-118MG cells expressing PDGFRβ. [1] |
| In vivo | IMC-2C5 showed significant antitumor activity in both OVCAR-8 and NCI-H460 xenograft models: At the end of treatment, it almost completely blocked the growth of OVCAR-8 tumors with a T/C of 39% and significantly slowed the growth of NCI-H460 tumors with a T/C of 60%. [1] |
| Alias | IMC2C5, Anti-PDGFRB/CD140b Antibody |
Storage & Solubility Information
| Storage | store at low temperature | store at -20°C | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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