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INCA-6
🥰Excellent
Catalog No. T21807Cas No. 3519-82-2
Alias Triptycene-1,4-quinone
INCA-6 (Triptycene-1,4-quinone) is a cell-permeable NFAT inhibitor that disrupts CN-NFAT signaling by targeting the NFAT(P) substrate at the calcineurin (CN) phosphatase site.
INCA-6
🥰Excellent
Purity: 99.88%
Catalog No. T21807Alias Triptycene-1,4-quinoneCas No. 3519-82-2
INCA-6 (Triptycene-1,4-quinone) is a cell-permeable NFAT inhibitor that disrupts CN-NFAT signaling by targeting the NFAT(P) substrate at the calcineurin (CN) phosphatase site.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $30 | In Stock | |
| 10 mg | $51 | In Stock | |
| 25 mg | $98 | In Stock | |
| 100 mg | $339 | In Stock | |
| 500 mg | $738 | In Stock |
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Purity:99.88%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | INCA-6 (Triptycene-1,4-quinone) is a cell-permeable NFAT inhibitor that disrupts CN-NFAT signaling by targeting the NFAT(P) substrate at the calcineurin (CN) phosphatase site. |
| In vitro | In human retinal microvascular endothelial cells, INCA-6 (1.0, 2.5 μM) significantly decreases VEGF and serum-induced proliferation without affecting baseline proliferation[1]. In 3-Hz cells, INCA-6 (5 μM) prevents transient outward K+ current downregulation[2]. INCA-6 (10 μM) significantly inhibits ATP-induced CXCL2 expression in rat primary microglia and BV-2 cells[3]. INCA-6 (5 μM) protein expression and reduces SERCA2 transcript levels with and without thapsigargin[4]. |
| In vivo | INCA-6 (2.5, 5.0, and 25.0 μM; intravitreal) significantly reduces pathologic neovascularization in oxygen-induced retinopathy and decreases the severity of OIR in a dose dependent manner[1]. |
| Alias | Triptycene-1,4-quinone |
| Molecular Weight | 284.31 |
| Formula | C20H12O2 |
| Cas No. | 3519-82-2 |
| Smiles | O=C1C=CC(=O)C2=C1C1c3ccccc3C2c2ccccc12 |
| Relative Density. | 1.38g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | DMSO: 2.84 mg/mL (10 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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