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INCA-6

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Purity:99.88%

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COA HPLC LCMS HNMR

INCA-6

Catalog No. T21807Cas No. 3519-82-2

INCA-6 (Triptycene-1,4-quinone) is a cell-permeable NFAT inhibitor. INCA-6 inhibits of CN-NFAT signaling by targeting of NFAT(P) substrate to the calcineurin (CN) phosphatase site.

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Pack Size	Price	Availability
5 mg	$30	In Stock
10 mg	$51	In Stock
25 mg	$98	In Stock
50 mg	$199	In Stock
100 mg	$339	In Stock
500 mg	$738	In Stock
1 mL x 10 mM (in DMSO)	$49	In Stock

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Product Introduction

Bioactivity

Description	INCA-6 (Triptycene-1,4-quinone) is a cell-permeable NFAT inhibitor. INCA-6 inhibits of CN-NFAT signaling by targeting of NFAT(P) substrate to the calcineurin (CN) phosphatase site.
In vitro	In human retinal microvascular endothelial cells, INCA-6 (1.0, 2.5 μM) significantly decreases VEGF and serum-induced proliferation without affecting baseline proliferation[1]. In 3-Hz cells, INCA-6 (5 μM) prevents transient outward K+ current downregulation[2]. INCA-6 (10 μM) significantly inhibits ATP-induced CXCL2 expression in rat primary microglia and BV-2 cells[3]. INCA-6 (5 μM) protein expression and reduces SERCA2 transcript levels with and without thapsigargin[4].
In vivo	INCA-6 (2.5, 5.0, and 25.0 μM; intravitreal) significantly reduces pathologic neovascularization in oxygen-induced retinopathy and decreases the severity of OIR in a dose dependent manner[1].
Alias	Triptycene-1,4-quinone

Chemical Properties

Molecular Weight	284.31
Formula	C20H12O2
Cas No.	3519-82-2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 2.84 mg/mL (10 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5173 mL	17.5864 mL	35.1729 mL	175.8644 mL
5 mM	0.7035 mL	3.5173 mL	7.0346 mL	35.1729 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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