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TNP

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Purity:98.25%

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COA HPLC HNMR

TNP

Catalog No. T4487Cas No. 519178-28-0

TNP (IP3K Inhibitor) is a cell-permeable inhibitor of IP6K1 and IP3K, with IC 50 values of 0.55 μM and 10.2 μM for IP6K1 and IP3K, respectively. TNP binds to the ATP-binding sites of both enzymes [1].

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Pack Size	Price	Availability
1 mg	$41	In Stock
5 mg	$97	In Stock
10 mg	$139	In Stock
25 mg	$313	In Stock
50 mg	$563	In Stock
1 mL x 10 mM (in DMSO)	$97	In Stock

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Product Introduction

Bioactivity

Description	TNP (IP3K Inhibitor) is a cell-permeable inhibitor of IP6K1 and IP3K, with IC 50 values of 0.55 μM and 10.2 μM for IP6K1 and IP3K, respectively. TNP binds to the ATP-binding sites of both enzymes [1].
Alias	IP3K Inhibitor

Chemical Properties

Molecular Weight	443.38
Formula	C20H16F3N7O2
Cas No.	519178-28-0

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 112.5 mg/mL (253.7 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2554 mL	11.2770 mL	22.5540 mL	112.7701 mL
5 mM	0.4511 mL	2.2554 mL	4.5108 mL	22.5540 mL
10 mM	0.2255 mL	1.1277 mL	2.2554 mL	11.2770 mL
20 mM	0.1128 mL	0.5639 mL	1.1277 mL	5.6385 mL
50 mM	0.0451 mL	0.2255 mL	0.4511 mL	2.2554 mL
100 mM	0.0226 mL	0.1128 mL	0.2255 mL	1.1277 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

TNP