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Irpagratinib
🥰Excellent
Catalog No. T79850Cas No. 2230974-62-4
Alias ABSK011, ABSK 011
Irpagratinib (ABSK011) is an orally active and highly effective FGFR4 antagonist with antitumor activity, inhibiting FGFR4 autophosphorylation and blocking FGFR4 signaling to downstream pathways. It is used in studies of gastrointestinal diseases and cancer.
Irpagratinib
🥰Excellent
Purity: 99.08%
Catalog No. T79850Alias ABSK011, ABSK 011Cas No. 2230974-62-4
Irpagratinib (ABSK011) is an orally active and highly effective FGFR4 antagonist with antitumor activity, inhibiting FGFR4 autophosphorylation and blocking FGFR4 signaling to downstream pathways. It is used in studies of gastrointestinal diseases and cancer.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $538 | In Stock | |
| 5 mg | $1,330 | In Stock | |
| 10 mg | $2,150 | In Stock | |
| 25 mg | $3,970 | In Stock | |
| 50 mg | $5,760 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $1,690 | In Stock |
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Purity:99.08%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Irpagratinib (ABSK011) is an orally active and highly effective FGFR4 antagonist with antitumor activity, inhibiting FGFR4 autophosphorylation and blocking FGFR4 signaling to downstream pathways. It is used in studies of gastrointestinal diseases and cancer. |
| Targets&IC50 | FGFR4:< 10 nM |
| In vitro | Irpagratinib inhibits FGFR4 with IC50 < 10 nM and shows at least 50-fold selectivity against other FGFR kinases. Irpagratinib has the ability to irreversibly modify Cys552. [1] |
| In vivo | Oral Irpagratinib strongly inhibited the growth of subcutaneous xenograft tumors dependent on FGFR4 activity and induced their regression. [1] |
| Alias | ABSK011, ABSK 011 |
| Molecular Weight | 570.59 |
| Formula | C28H32F2N6O5 |
| Cas No. | 2230974-62-4 |
| Smiles | N(C1=NC=2C(=NC(=CC2C=N1)C3=C(F)C(OC)=CC(OC)=C3F)N4CC(OC)(C)C4)[C@H]5[C@@H](NC(C=C)=O)CCOC5 |
Storage & Solubility Information
| Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (140.21 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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