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Irtemazole

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Purity:99.79%

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COA HNMR HPLC LCMS

Irtemazole

Catalog No. T32194Cas No. 129369-64-8

Irtemazole (R 60844) is a novel uricosuric substance that is valuable in the treatment of hyperuricemia and gout.

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Pack Size	Price	Availability
1 mg	$112	In Stock
5 mg	$260	In Stock
10 mg	$390	In Stock
25 mg	$653	In Stock
50 mg	$928	In Stock
100 mg	$1,260	In Stock
500 mg	$2,530	In Stock

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Product Introduction

Bioactivity

Description	Irtemazole (R 60844) is a novel uricosuric substance that is valuable in the treatment of hyperuricemia and gout.
In vivo	Irtemazole (12.5 to 50 mg; oral; 6 patients) caused a maximal decrease in plasma uric acid (after 8 to 12 h) of 46.5%. The uricosuric effect began during the first 60 min after drug administration and it lasted for 7 to 24 h. Renal uric acid excretion returned to its base line value after 8 to 16 h and uric acid clearance after 10.0 to 12.0 h. Doses of irtemazole between 12.5 and 37.5 mg produced a dose-related rise in the uricosuric effect. There was no essential difference between the uricosuric effect of 37.5 mg and 50 mg irtemazole. The D50 dose (that producing a half-maximal effect) was between 16.3 mg and 34.2 mg, (average 24.7 mg). The value of irtemazole in the management of hyperuricaemia and gout remains to be determined.[2]
Alias	R60844, R-60844, R 60844

Chemical Properties

Molecular Weight	288.35
Formula	C18H16N4
Cas No.	129369-64-8

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (190.74 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4680 mL	17.3400 mL	34.6801 mL	173.4004 mL
5 mM	0.6936 mL	3.4680 mL	6.9360 mL	34.6801 mL
10 mM	0.3468 mL	1.7340 mL	3.4680 mL	17.3400 mL
20 mM	0.1734 mL	0.8670 mL	1.7340 mL	8.6700 mL
50 mM	0.0694 mL	0.3468 mL	0.6936 mL	3.4680 mL
100 mM	0.0347 mL	0.1734 mL	0.3468 mL	1.7340 mL

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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Keywords

Irtemazole