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Isoescin IB

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Purity:99.76%

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COA HNMR HPLC

Isoescin IB

Catalog No. TN1777Cas No. 219944-46-4

Isoescin IB is a natural product from Aesculus hippocastanum L. Isoescin IB and Escin IB are the chief active ingredients in escin.

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Pack Size	Price	Availability
1 mg	$115	In Stock
5 mg	$280	In Stock
10 mg	$415	In Stock
25 mg	$688	In Stock
50 mg	Inquiry	In Stock
1 mL x 10 mM (in DMSO)	$498	In Stock

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Product Introduction

Bioactivity

Description

Isoescin IB is a natural product from Aesculus hippocastanum L.

In vivo

Five groups of Wistar rats (n=6 per group) were treated with either an intravenous (IV) dose (2.78mg/kg) of sodium escinate (corresponding to 0.5mg/kg of Escin IB and 0.5mg/kg of Isoescin IB), an IV dose (0.5mg/kg) and an oral dose (4mg/kg) of pure Escin IB or Isoescin IB. The administration of sodium escinate, which contains the two isomers, gave rise to higher terminal phase half-life (t1/2) and mean residence time (MRT) values for both Escin IB and Isoescin IB compared to the corresponding compounds administered alone. The absorption of Escin IB and Isoescin IB was very poor, with the oral bioavailability (F) values of <2% observed for both compounds. The two compounds were found to isomerize in vivo, wherein the conversion of Escin IB to Isoescin IB was much easier than that of Isoescin IB to Escin IB[1].

Chemical Properties

Molecular Weight	1131.26
Formula	C55H86O24
Cas No.	219944-46-4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (88.40 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.8840 mL	4.4199 mL	8.8397 mL	44.1985 mL
5 mM	0.1768 mL	0.8840 mL	1.7679 mL	8.8397 mL
10 mM	0.0884 mL	0.4420 mL	0.8840 mL	4.4199 mL
20 mM	0.0442 mL	0.2210 mL	0.4420 mL	2.2099 mL
50 mM	0.0177 mL	0.0884 mL	0.1768 mL	0.8840 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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