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JAK 3 inhibitor IV

JAK 3 inhibitor IV
JAK 3 inhibitor IV (ZM 39923 hydrochloride) is a JAK1/3 inhibitor with pIC50 of 4.4/7.1, almost no activity to JAK2 and modestly potent to EGFR; also found to be sensitive to transglutaminase.
Catalog No. T2460Cas No. 58753-54-1
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JAK 3 inhibitor IV

Catalog No. T2460Alias ZM 39923 hydrochloride, Jak3 inhibitor IVCas No. 58753-54-1

JAK 3 inhibitor IV (ZM 39923 hydrochloride) is a JAK1/3 inhibitor with pIC50 of 4.4/7.1, almost no activity to JAK2 and modestly potent to EGFR; also found to be sensitive to transglutaminase.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
5 mg$62Backorder
10 mg$109Backorder
25 mg$201Backorder
50 mg$333Backorder
1 mL x 10 mM (in DMSO)$62Backorder
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Product Introduction

Bioactivity
Description
JAK 3 inhibitor IV (ZM 39923 hydrochloride) is a JAK1/3 inhibitor with pIC50 of 4.4/7.1, almost no activity to JAK2 and modestly potent to EGFR; also found to be sensitive to transglutaminase.
Targets&IC50
JAK1:4.4(pIC50), JAK3:7.1(pIC50)
AliasZM 39923 hydrochloride, Jak3 inhibitor IV
Chemical Properties
Molecular Weight241.33
FormulaC16H19NO
Cas No.58753-54-1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 36.8 mg/mL (100 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM4.1437 mL20.7185 mL41.4370 mL207.1852 mL
5 mM0.8287 mL4.1437 mL8.2874 mL41.4370 mL
10 mM0.4144 mL2.0719 mL4.1437 mL20.7185 mL
20 mM0.2072 mL1.0359 mL2.0719 mL10.3593 mL
50 mM0.0829 mL0.4144 mL0.8287 mL4.1437 mL
100 mM0.0414 mL0.2072 mL0.4144 mL2.0719 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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