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JAK 3 inhibitor IV
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Catalog No. T2460Cas No. 58753-54-1
Alias ZM 39923 hydrochloride, Jak3 inhibitor IV
JAK 3 inhibitor IV (ZM 39923 hydrochloride) is a JAK1/3 inhibitor with pIC50 of 4.4/7.1, almost no activity to JAK2 and modestly potent to EGFR; also found to be sensitive to transglutaminase.
JAK 3 inhibitor IV
😃Good
Catalog No. T2460Alias ZM 39923 hydrochloride, Jak3 inhibitor IVCas No. 58753-54-1
JAK 3 inhibitor IV (ZM 39923 hydrochloride) is a JAK1/3 inhibitor with pIC50 of 4.4/7.1, almost no activity to JAK2 and modestly potent to EGFR; also found to be sensitive to transglutaminase.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $62 | Backorder | |
| 10 mg | $109 | Backorder | |
| 25 mg | $201 | Backorder | |
| 50 mg | $333 | Backorder | |
| 1 mL x 10 mM (in DMSO) | $62 | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | JAK 3 inhibitor IV (ZM 39923 hydrochloride) is a JAK1/3 inhibitor with pIC50 of 4.4/7.1, almost no activity to JAK2 and modestly potent to EGFR; also found to be sensitive to transglutaminase. |
| Targets&IC50 | JAK1:4.4（pIC50）, JAK3:7.1（pIC50） |
| Alias | ZM 39923 hydrochloride, Jak3 inhibitor IV |
| Molecular Weight | 241.33 |
| Formula | C16H19NO |
| Cas No. | 58753-54-1 |
| Smiles | O=C(C1=CC=C2C=CC=CC2=C1)CCNC(C)C |
| Relative Density. | 1.047 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 36.8 mg/mL (100 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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