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Flonoltinib
🥰Excellent
Catalog No. T11707Cas No. 2387765-27-5
Alias JAK2/FLT3-IN-1
Flonoltinib (JAK2/FLT3-IN-1) is an orally active and potent JAK2/FLT3 inhibitor, inhibiting JAK2, FLT3, JAK1, and JAK3. Flonoltinib has anti-cancer activity and can be used for studying myeloproliferative neoplasms.
Flonoltinib
🥰Excellent
Catalog No. T11707Alias JAK2/FLT3-IN-1Cas No. 2387765-27-5
Flonoltinib (JAK2/FLT3-IN-1) is an orally active and potent JAK2/FLT3 inhibitor, inhibiting JAK2, FLT3, JAK1, and JAK3. Flonoltinib has anti-cancer activity and can be used for studying myeloproliferative neoplasms.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $253 | In Stock | |
| 5 mg | $619 | In Stock | |
| 10 mg | $987 | In Stock | |
| 25 mg | $1,530 | In Stock | |
| 50 mg | $1,980 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $593 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Flonoltinib (JAK2/FLT3-IN-1) is an orally active and potent JAK2/FLT3 inhibitor, inhibiting JAK2, FLT3, JAK1, and JAK3. Flonoltinib has anti-cancer activity and can be used for studying myeloproliferative neoplasms. |
| Targets&IC50 | JAK1:26 nM, JAK3:39 nM, FLT3:4 nM, JAK2:0.7 nM |
| In vitro | Flonoltinib (0.005-0.1 μM; for 2 hours) has a dose-dependent effect on the induction of apoptosis in the MV4-11 cells. Flonoltinib (0.008-1 μM; for 2 hours) down-regulates p-FLT3 in a dose-dependent manner from 0.008 to 1 μM. Flonoltinib (0.005-0.1 μM; for 2 hours) strongly induces cell cycle arrest with a G1/G0 percentage of 85% at 100 nM in the MV4-11 cells. |
| In vivo | Flonoltinib exhibits significant antitumor effects and the tumor growth inhibitory rates (TGI) were respective 58% and 93% in the MV4-11-bearing mice model. |
| Alias | JAK2/FLT3-IN-1 |
| Molecular Weight | 467.58 |
| Formula | C25H34FN7O |
| Cas No. | 2387765-27-5 |
| Smiles | FC1=CC(=CC=C1N2CCC(N(C)CCO)CC2)NC=3N=CC(=C(N3)C=4C=NN(C4)C(C)C)C |
| Relative Density. | 1.26 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 20 mg/mL (42.77 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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