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JNJ-46281222
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Catalog No. T15618Cas No. 1254980-38-5
JNJ-46281222 is a metabotropic glutamate (mGlu) 2-selective, highly potent positive allosteric modulator (PAM) with nanomolar affinity (Kd = 1.7 nM) and high modulatory potency (pEC50 = 7.71).
JNJ-46281222
😃Good
Catalog No. T15618Cas No. 1254980-38-5
JNJ-46281222 is a metabotropic glutamate (mGlu) 2-selective, highly potent positive allosteric modulator (PAM) with nanomolar affinity (Kd = 1.7 nM) and high modulatory potency (pEC50 = 7.71).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,430 | 8-10 weeks | |
| 50 mg | $1,860 | 8-10 weeks | |
| 100 mg | $3,190 | 8-10 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | JNJ-46281222 is a metabotropic glutamate (mGlu) 2-selective, highly potent positive allosteric modulator (PAM) with nanomolar affinity (Kd = 1.7 nM) and high modulatory potency (pEC50 = 7.71). |
| Targets&IC50 | mGluR2:1.7 nM (kd) |
| In vitro | Compared with WT, JNJ‐4628122 binds to the selected mGlu2?receptor mutants is significantly decreased by approximately 10‐fold. Mutations F643A and N735D are selected, in transfected mGlu2?WT and mutant receptors in CHO‐K1 cells [1]. |
| Molecular Weight | 414.47 |
| Formula | C23H25F3N4 |
| Cas No. | 1254980-38-5 |
| Relative Density. | 1.35 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 62.5 mg/mL (150.79 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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