JNJ-46281222

Name: JNJ-46281222
Brand: TargetMol
SKU: T15618
Price: 35 USD
Availability: InStock
Rating: 4.5 (1 reviews)

Catalog No. T15618Cas No. 1254980-38-5

JNJ-46281222 is a metabotropic glutamate (mGlu) 2-selective, highly potent positive allosteric modulator (PAM) with nanomolar affinity (Kd = 1.7 nM) and high modulatory potency (pEC50 = 7.71).

JNJ-46281222

Catalog No. T15618Cas No. 1254980-38-5

JNJ-46281222 is a metabotropic glutamate (mGlu) 2-selective, highly potent positive allosteric modulator (PAM) with nanomolar affinity (Kd = 1.7 nM) and high modulatory potency (pEC50 = 7.71).

Pack Size	Price	Availability
25 mg	$1,430	8-10 weeks
50 mg	$1,860	8-10 weeks
100 mg	$3,190	8-10 weeks

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Product Introduction

Bioactivity

Description	JNJ-46281222 is a metabotropic glutamate (mGlu) 2-selective, highly potent positive allosteric modulator (PAM) with nanomolar affinity (Kd = 1.7 nM) and high modulatory potency (pEC50 = 7.71).
Targets&IC50	mGluR2:1.7 nM (kd)
In vitro	Compared with WT, JNJ‐4628122 binds to the selected mGlu2?receptor mutants is significantly decreased by approximately 10‐fold. Mutations F643A and N735D are selected, in transfected mGlu2?WT and mutant receptors in CHO‐K1 cells [1].

Chemical Properties

Molecular Weight	414.47
Formula	C₂₃H₂₅F₃N₄
Cas No.	1254980-38-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 62.5 mg/mL (150.79 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4127 mL	12.0636 mL	24.1272 mL	120.6360 mL
5 mM	0.4825 mL	2.4127 mL	4.8254 mL	24.1272 mL
10 mM	0.2413 mL	1.2064 mL	2.4127 mL	12.0636 mL
20 mM	0.1206 mL	0.6032 mL	1.2064 mL	6.0318 mL
50 mM	0.0483 mL	0.2413 mL	0.4825 mL	2.4127 mL
100 mM	0.0241 mL	0.1206 mL	0.2413 mL	1.2064 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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