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JNJ-55511118
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Catalog No. T25558Cas No. 2036081-86-2
Alias JNJ55511118, JNJ 55511118
JNJ-55511118 is a highly efficient and selective TARP γ8 negative allosteric modulator with anticonvulsant and neuroprotective activities. By reducing the peak current of AMPAR containing γ8, it can be used for research on chronic operant alcohol self-administration.
JNJ-55511118
😃Good
Catalog No. T25558Alias JNJ55511118, JNJ 55511118Cas No. 2036081-86-2
JNJ-55511118 is a highly efficient and selective TARP γ8 negative allosteric modulator with anticonvulsant and neuroprotective activities. By reducing the peak current of AMPAR containing γ8, it can be used for research on chronic operant alcohol self-administration.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $78 | 35 days | |
| 5 mg | $233 | 35 days | |
| 10 mg | $423 | 35 days | |
| 25 mg | $953 | 35 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | JNJ-55511118 is a highly efficient and selective TARP γ8 negative allosteric modulator with anticonvulsant and neuroprotective activities. By reducing the peak current of AMPAR containing γ8, it can be used for research on chronic operant alcohol self-administration. |
| In vitro | In the competition binding assay, JNJ-55511118 can completely replace the radioligand with a Ki value of 26 nM. [1] |
| Alias | JNJ55511118, JNJ 55511118 |
| Molecular Weight | 328.67 |
| Formula | C14H8ClF3N2O2 |
| Cas No. | 2036081-86-2 |
| Smiles | O=C1NC=2C=CC(=CC2N1)C=3C(Cl)=CC=CC3OC(F)(F)F |
| Relative Density. | 1.462 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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