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KU 59403
Catalog No. T15673Cas No. 845932-30-1
KU 59403 is a selective and potent ATM inhibitor with antitumor and anticancer activity, inhibits ATM, DNA-PK and PI3K, and is often used in combination therapy with PARP or ATR inhibitors to slow the progression of cancer.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $882 | 10-14 weeks | |
| 50 mg | $1,170 | 10-14 weeks | |
| 100 mg | $1,770 | 10-14 weeks |
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CitedProduct Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | KU 59403 is a selective and potent ATM inhibitor with antitumor and anticancer activity, inhibits ATM, DNA-PK and PI3K, and is often used in combination therapy with PARP or ATR inhibitors to slow the progression of cancer. |
| In vitro | In LoVo, HCT116, and SW620, U2OS, and MDA-MB-231 cells, KU 59403 (1 μM; 16 hours) exhibited at least 1000-fold specificity for ATM over other tested members of the PI3K family[1]. |
| In vivo | In CD-1 nude mice implanted with SW620 or HCT116-N7 human cancer cell lines at 1×107 cells per animal subcutaneously, KU 59403 (6, 12.5, and 25 mg/kg; intraperitoneal administration twice daily (0 and 4 hours) and 12.5 mg/kg once daily) alone caused a modest tumor growth delay of 4 days (time to RTV4 = 10.5 days)[1]. |
| Alias | KU-59403, KU59403 |
| Molecular Weight | 564.72 |
| Formula | C29H32N4O4S2 |
| Cas No. | 845932-30-1 |
| Storage | store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||
| Solubility Information | DMSO: 5 mg/mL (8.86 mM) | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
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