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KU 59403
😃Good
Catalog No. T15673Cas No. 845932-30-1
Alias KU-59403, KU59403
KU 59403 is a selective and potent ATM inhibitor with antitumor and anticancer activity, inhibits ATM, DNA-PK and PI3K, and is often used in combination therapy with PARP or ATR inhibitors to slow the progression of cancer.
KU 59403
😃Good
Purity: 99.10%
Catalog No. T15673Alias KU-59403, KU59403Cas No. 845932-30-1
KU 59403 is a selective and potent ATM inhibitor with antitumor and anticancer activity, inhibits ATM, DNA-PK and PI3K, and is often used in combination therapy with PARP or ATR inhibitors to slow the progression of cancer.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $882 | 10-14 weeks | |
| 50 mg | $1,170 | 10-14 weeks | |
| 100 mg | $1,770 | 10-14 weeks |
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Purity:99.10%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | KU 59403 is a selective and potent ATM inhibitor with antitumor and anticancer activity, inhibits ATM, DNA-PK and PI3K, and is often used in combination therapy with PARP or ATR inhibitors to slow the progression of cancer. |
| Targets&IC50 | ATM:3 nM |
| In vitro | In LoVo, HCT116, and SW620, U2OS, and MDA-MB-231 cells, KU 59403 (1 μM; 16 hours) exhibited at least 1000-fold specificity for ATM over other tested members of the PI3K family[1]. |
| In vivo | KU59403 at a daily dose of 12.5 mg/kg induces sensitization, while increasing the dose to 25 mg/kg twice daily results in the greatest chemo-sensitisation. Without significantly increased toxicity, it exhibits a 3-fold increase in BMY-40481-induced tumor growth delay in SW620 and HCT116-N7 xenografts [1]. |
| Alias | KU-59403, KU59403 |
| Molecular Weight | 564.72 |
| Formula | C29H32N4O4S2 |
| Cas No. | 845932-30-1 |
| Smiles | CN1CCN(CCC(=O)Nc2ccc3Sc4c(Sc3c2)cccc4-c2cc(=O)cc(o2)N2CCOCC2)CC1 |
| Relative Density. | 1.368 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||
| Solubility Information | DMSO: 5 mg/mL (8.86 mM), Sonication is recommended. | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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