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L-AP4
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Catalog No. T15692Cas No. 23052-81-5
Alias L-APB, L-AP 4
L-APB is an effective and specific agonist for the group III mGluRs (EC50s: 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6, and mGlu7 receptors, respectively).
L-AP4
😃Good
Catalog No. T15692Alias L-APB, L-AP 4Cas No. 23052-81-5
L-APB is an effective and specific agonist for the group III mGluRs (EC50s: 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6, and mGlu7 receptors, respectively).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $140 | 35 days | |
| 5 mg | $243 | 35 days | |
| 10 mg | $415 | 35 days | |
| 50 mg | $1,720 | 35 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | L-APB is an effective and specific agonist for the group III mGluRs (EC50s: 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6, and mGlu7 receptors, respectively). |
| Targets&IC50 | mGlu7:249 μM (EC50), mGlu4:0.13 μM (EC50), mGlu6:1.0 μM (EC50), mGlu8:0.29 μM (EC50) |
| In vivo | L-APB(5 to 30 μg; intrathecal injection) obviously enhances the paw withdrawal threshold in response to the application of von Frey filaments in eight nerve-ligated rats in a dose-dependent manner. The maximal effect of L-APB appears within 45 min and gradually subsided in 120 min following intrathecal administration. Paw withdrawal threshold in response to the application of von Frey filaments before spinal nerve ligation is 22.6±2.4 g. The mechanical threshold decreases significantly (2.3±0.5 g, P<0.05) within 10 days after nerve ligation and remains stable for at least 8 weeks [2]. |
| Alias | L-APB, L-AP 4 |
| Molecular Weight | 183.1 |
| Formula | C4H10NO5P |
| Cas No. | 23052-81-5 |
| Relative Density. | 1.628 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: 50 mg/mL (273.07 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
H2O
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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