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LCL521 dihydrochloride

Name: LCL521 dihydrochloride
Brand: TargetMol
SKU: T11835L
Rating: 4.5 (1 reviews)

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Catalog No. T11835LCas No. 1226759-47-2

Alias 1,3DMG-B13 dihydrochloride

LCL521 dihydrochloride is a compound that functions as an inhibitor of both acid ceramidase (ACDase) and lysosomal acid sphingomyelinase (ASMase).

LCL521 dihydrochloride

😃Good

Catalog No. T11835LAlias 1,3DMG-B13 dihydrochlorideCas No. 1226759-47-2

LCL521 dihydrochloride is a compound that functions as an inhibitor of both acid ceramidase (ACDase) and lysosomal acid sphingomyelinase (ASMase).

Pack Size	Price	Availability
25 mg	$987	6-8 weeks
50 mg	$1,360	6-8 weeks
100 mg	$2,190	6-8 weeks

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Product Introduction

Bioactivity

Description	LCL521 dihydrochloride is a compound that functions as an inhibitor of both acid ceramidase (ACDase) and lysosomal acid sphingomyelinase (ASMase).
In vitro	LCL521 (10μM) causes a time-dependent (1 hours and 5 hours) decrease of the α-ACDase form in MCF7 cells[1].
Alias	1,3DMG-B13 dihydrochloride

Chemical Properties

Molecular Weight	665.69
Formula	C₃₁H₅₄Cl₂N₄O₇
Cas No.	1226759-47-2
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 20.83 mg/mL (31.29 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5022 mL	7.5110 mL	15.0220 mL	75.1100 mL
5 mM	0.3004 mL	1.5022 mL	3.0044 mL	15.0220 mL
10 mM	0.1502 mL	0.7511 mL	1.5022 mL	7.5110 mL
20 mM	0.0751 mL	0.3756 mL	0.7511 mL	3.7555 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

LCL-521 DihydrochlorideLCL-521 dihydrochlorideLCL521 DihydrochlorideLCL521 dihydrochlorideLCL-521LCL521LCL 521 DihydrochlorideLCL 521ACDase, ASMase1,3DMG-B13 Dihydrochloride1,3DMG-B13