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LCL521
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Catalog No. T11835Cas No. 1226851-11-1
LCL521 inhibits lysosomal acid sphingomyelinase (ASMase).LCL521 is an acid ceramidase (ACDase) inhibitor.
LCL521
😃Good
Catalog No. T11835Cas No. 1226851-11-1
LCL521 inhibits lysosomal acid sphingomyelinase (ASMase).LCL521 is an acid ceramidase (ACDase) inhibitor.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $987 | 6-8 weeks | |
| 50 mg | $1,360 | 6-8 weeks | |
| 100 mg | $2,190 | 6-8 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | LCL521 inhibits lysosomal acid sphingomyelinase (ASMase).LCL521 is an acid ceramidase (ACDase) inhibitor. |
| In vitro | LCL521 (1 µM) effectively inhibited ACDase in MCF7 cells, but the effects were transient. LCL521 (10 µM) caused a profound decrease of sphingosine and an increase of ceramide, but additionally affected the processing and regeneration of the ACDase protein, with biphasic and reversible effects on the expression of ACDase, which paralleled the long-term changes of cellular sphingosine and ceramide. The higher concentrations of LCL521 also inhibited Dihydroceramide desaturase (DES-1). In summary, LCL521 exhibits significant effects on ACDase in a dose and time-dependent manner.[2] |
| In vivo | When PDT-treated SCCVII cells are used to vaccinate SCCVII tumor-bearing mice, adjuvant LCL521 treatment (75 mg/kg; i.p.) resulted in marked retardation of tumor growth. This effect can be attributed to the capacity of LCL521 to effectively restrict the activity of two main immunoregulatory cell populations (Tregs and myeloid-derived suppressor cells, MDSCs) that are known to hinder the efficacy of PDT vaccines. The interaction of LCL521 with PDT-based antitumor mechanisms is dominated by immune system contribution that includes overriding the effects of immunoregulatory cells but could also include a tacit contribution from boosting direct tumor cell kill.[3] |
| Molecular Weight | 592.77 |
| Formula | C31H52N4O7 |
| Cas No. | 1226851-11-1 |
| Smiles | [C@@H]([C@H](NC(CCCCCCCCCCCCC)=O)COC(CN(C)C)=O)(OC(CN(C)C)=O)C1=CC=C(N(=O)=O)C=C1 |
| Relative Density. | 1.093 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 148.5 mg/mL (250.5 mM), Sonication is recommended. Ethanol: 90.0 mg/mL (151.8 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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