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LY309887 is a potent inhibitor of glycinamide ribonucleotide formyltransferase (Ki: 6.5 nM) with antitumor activity.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $1,400 | 10-14 weeks | |
50 mg | $1,820 | 10-14 weeks | |
100 mg | $2,810 | 10-14 weeks |
Description | LY309887 is a potent inhibitor of glycinamide ribonucleotide formyltransferase (Ki: 6.5 nM) with antitumor activity. |
Targets&IC50 | FRα:1.78 nM(ki), FRβ:18.2 nM(ki), GARFT:(ki)6.5 nM |
In vitro | LY309887 is significantly cytotoxic against the human leukemia cell line CCRF-CEM (IC50: 9.9 nM). LY309887 also has high affinity at human folate receptor (FR)α and FRβ (Ki, 1.78 nM, and 18.2 nM, respectively) . |
In vivo | In mice bearing C3H mammary cancer cells, LY309887 (3 mg/kg-100 mg/kg, i.p.) displays complete inhibition on the tumor growth. |
Molecular Weight | 449.48 |
Formula | C19H23N5O6S |
Cas No. | 127228-54-0 |
Relative Density. | 1.68 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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