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Malic enzyme inhibitor ME1

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Catalog No. T11940Cas No. 522649-59-8
Alias ME1

Malic enzyme inhibitor ME1 (ME1) is a specific inhibitor of Malic enzyme (IC50 = 0.15 μM). Malic enzyme inhibitor ME1 reduces cell viability/metabolic activity.

Malic enzyme inhibitor ME1

Malic enzyme inhibitor ME1

🥰Excellent
Purity: 99.93%
Catalog No. T11940Alias ME1Cas No. 522649-59-8
Malic enzyme inhibitor ME1 (ME1) is a specific inhibitor of Malic enzyme (IC50 = 0.15 μM). Malic enzyme inhibitor ME1 reduces cell viability/metabolic activity.
Pack SizePriceAvailabilityQuantity
1 mg63 €In Stock
5 mg188 €In Stock
10 mg344 €In Stock
25 mg585 €In Stock
50 mg833 €In Stock
100 mg1.121 €In Stock
500 mg2.270 €In Stock
1 mL x 10 mM (in DMSO)151 €In Stock
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Purity:99.93%
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Product Introduction

Bioactivity
Description
Malic enzyme inhibitor ME1 (ME1) is a specific inhibitor of Malic enzyme (IC50 = 0.15 μM). Malic enzyme inhibitor ME1 reduces cell viability/metabolic activity.
Targets&IC50
Malic enzyme:0.15 μM
In vitro
In HCT116 cells and HT29 cells, Malic enzyme inhibitor ME1 (50 μM) significantly reduces the total number of cells and cell colonies in a dose-dependent manner. In MTS cells, Malic enzyme inhibitor ME1 decreases the viability and metabolic activities of cells[2].
AliasME1
Chemical Properties
Molecular Weight351.4
FormulaC20H21N3O3
Cas No.522649-59-8
SmilesOc1ccc(cc1)N1CCN(CC1)C1CC(=O)N(C1=O)c1ccccc1
Relative Density.1.342 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 90.0 mg/mL (256.1 mM), Sonication and heating to 60℃ are recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.8458 mL14.2288 mL28.4576 mL142.2880 mL
5 mM0.5692 mL2.8458 mL5.6915 mL28.4576 mL
10 mM0.2846 mL1.4229 mL2.8458 mL14.2288 mL
20 mM0.1423 mL0.7114 mL1.4229 mL7.1144 mL
50 mM0.0569 mL0.2846 mL0.5692 mL2.8458 mL
100 mM0.0285 mL0.1423 mL0.2846 mL1.4229 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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