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Melinamide

Name: Melinamide
Brand: TargetMol
SKU: T16036
Price: 37 EUR
Availability: InStock
Rating: 4.5 (1 reviews)

Catalog No. T16036Cas No. 14417-88-0

Alias DL-N-(α-Methylbenzyl)linoleamide, AC 223

Melinamide is an amide derivative of an unsaturated long-chain fatty acid and also is an inhibitor of cholesterol absorption (IC50: 20.9 μM).

Melinamide

Catalog No. T16036Alias DL-N-(α-Methylbenzyl)linoleamide, AC 223Cas No. 14417-88-0

Melinamide is an amide derivative of an unsaturated long-chain fatty acid and also is an inhibitor of cholesterol absorption (IC50: 20.9 μM).

Pack Size	Price	Availability
2 mg	$95	5 days
5 mg	$163	5 days
10 mg	$297	5 days
1 mL x 10 mM (in DMSO)	$178	5 days

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Product Introduction

Bioactivity

Description	Melinamide is an amide derivative of an unsaturated long-chain fatty acid and also is an inhibitor of cholesterol absorption (IC50: 20.9 μM).
Targets&IC50	Cholesterol:20.9 μM
In vitro	D-Melinamide exhibits greater inhibitory efficacy compared to L-Melinamide. It has been observed that DL-Melinamide effectively suppresses acyl CoA: cholesterol acyltransferase (ACAT) activity in mucosal microsomes, achieving 50% inhibition at an approximate concentration of 0.5 μM. Kinetic analysis has revealed that DL-Melinamide acts as an uncompetitive inhibitor against acyl CoA: cholesterol acyltransferase [2].
In vivo	Melinamide induces a substantial decrease in the enhanced intestinal ACAT activity in diabetic rats but does not affect intestinal cholesterol esterase activity. Melinamide is a new hypocholesterolaemic drug. A marked improvement of hypercholesterolaemia in cholesterol-fed diabetic rats occurs concomitantly with the drug treatment[3].
Alias	DL-N-(α-Methylbenzyl)linoleamide, AC 223

Chemical Properties

Molecular Weight	383.61
Formula	C₂₆H₄₁NO
Cas No.	14417-88-0

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

DL-N-(alpha-Methylbenzyl)linoleamideMelinamideDL-N-(a-Methylbenzyl)linoleamideAC-223AC223