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MFZ 10-7 hydrochloride

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Catalog No. T12025Cas No. 1779796-36-9

MFZ 10-7 hydrochloride is a highly potent and selective negative allosteric modulator of mGluR5 (NAM).

MFZ 10-7 hydrochloride

MFZ 10-7 hydrochloride

😃Good
Catalog No. T12025Cas No. 1779796-36-9
MFZ 10-7 hydrochloride is a highly potent and selective negative allosteric modulator of mGluR5 (NAM).
Pack SizePriceAvailabilityQuantity
25 mg1.444 €1-2 weeks
50 mg1.881 €1-2 weeks
100 mg2.375 €1-2 weeks
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Product Introduction

Bioactivity
Description
MFZ 10-7 hydrochloride is a highly potent and selective negative allosteric modulator of mGluR5 (NAM).
Targets&IC50
mGluR5 (rat):0.67 nM (ki)
In vitro
MFZ 10-7 hydrochloride has approximately 1150- and 3000-fold lower affinity for MAO-B and TXA2, respectively, compared to mGluR5[1].
In vivo
MFZ 10-7 hydrochloride decreases the rate of oral sucrose self-administration without affecting the overall sucrose consumption[1].
Chemical Properties
Molecular Weight272.71
FormulaC15H10ClFN2
Cas No.1779796-36-9
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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