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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $118 | In Stock | |
5 mg | $266 | In Stock | |
10 mg | $393 | In Stock | |
25 mg | $592 | In Stock | |
50 mg | $833 | In Stock | |
100 mg | $1,120 | In Stock | |
200 mg | $1,520 | In Stock |
Description | MMK 1 acetate is an agonist of formyl peptide receptor 2 (FPR2), which was previously known as formyl peptide receptor-like 1 (FPRL1) [1]. |
In vitro | MMK1 induced calcium flux in CHO cells expressing human FPR2 and Gα16 (EC50 = <2 nM) but not in CHO cells expressing Gα16 alone or in combination with FPR1 (EC50s = >10,000 nM for both). It induced chemotaxis of isolated human peripheral blood monocytes and neutrophils in a concentration-dependent manner [2]. MMK1 (10 µM) increases production of the proinflammatory cytokines IL-1β and IL-6 in isolated human monocytes [3]. |
In vivo | Intracerebroventricular administration of MMK1 (100 pmol/mouse) increases the percentage of time spent in the open arms of the elevated plus maze in mice, indicating anxiolytic-like activity [3]. |
Alias | MMK 1 acetate(271246-66-3 free base) |
Molecular Weight | 1671.01 |
Formula | C77H127N19O20S |
Cas No. |
Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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