Shopping Cart

Remove All

Your shopping cart is currently empty

MSC2504877

Select Batch

Resource Download

COA HNMR HPLC

MSC2504877

Catalog No. T60098Cas No. 1460286-21-8

MSC2504877 is an inhibitor of tankyrase and enhances the effects of clinical CDK4/6 inhibitors. MSC2504877 suppresses the upregulation of Cyclin D2 and Cyclin E2 caused by palbociclib and enhances the suppression of phospho-Rb.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
1 mg	$39	In Stock
5 mg	$91	In Stock
10 mg	$145	In Stock
25 mg	$283	In Stock
50 mg	$415	In Stock
100 mg	$592	In Stock
1 mL x 10 mM (in DMSO)	$91	In Stock

Bulk & Custom

Add to Cart

Questions

Related Compound Libraries of "MSC2504877"

Product Introduction

Bioactivity

Description	MSC2504877 is an inhibitor of tankyrase and enhances the effects of clinical CDK4/6 inhibitors. MSC2504877 suppresses the upregulation of Cyclin D2 and Cyclin E2 caused by palbociclib and enhances the suppression of phospho-Rb.
Alias	3-(4-(2-Hydroxypropan-2-yl)phenyl)-6-methylpyrrolo[1,2-a]pyrazin-1(2H)-one

Chemical Properties

Molecular Weight	282.34
Formula	C17H18N2O2
Cas No.	1460286-21-8

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 3.6 mg/mL (12.75 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5418 mL	17.7091 mL	35.4183 mL	177.0915 mL
5 mM	0.7084 mL	3.5418 mL	7.0837 mL	35.4183 mL
10 mM	0.3542 mL	1.7709 mL	3.5418 mL	17.7091 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc