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Naproxen etemesil

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Catalog No. T16272Cas No. 385800-16-8
Alias MX 1094, LT-NS 001

Naproxen is a COX-1 and COX-2 inhibitor (IC50s: 8.72 and 5.15 μM, respectively in cell assay). Naproxen etemesil is a lipophilic and non-acidic prodrug of naproxen. It is hydrolyzed to pharmacologically active Naproxen once absorbed.

Naproxen etemesil

Naproxen etemesil

😃Good
Catalog No. T16272Alias MX 1094, LT-NS 001Cas No. 385800-16-8
Naproxen is a COX-1 and COX-2 inhibitor (IC50s: 8.72 and 5.15 μM, respectively in cell assay). Naproxen etemesil is a lipophilic and non-acidic prodrug of naproxen. It is hydrolyzed to pharmacologically active Naproxen once absorbed.
Pack SizePriceAvailabilityQuantity
25 mg$8546-8 weeks
50 mg$1,1106-8 weeks
100 mg$1,6106-8 weeks
1 mL x 10 mM (in DMSO)$2596-8 weeks
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Product Introduction

Bioactivity
Description
Naproxen is a COX-1 and COX-2 inhibitor (IC50s: 8.72 and 5.15 μM, respectively in cell assay). Naproxen etemesil is a lipophilic and non-acidic prodrug of naproxen. It is hydrolyzed to pharmacologically active Naproxen once absorbed.
Targets&IC50
COX-1:8.72 μM, COX-2:5.15 μM
In vitro
Naproxen is a well known nonsteroidal anti-inflammatory drug. Naproxen is an approximately equipotent inhibitor of COX-1 and COX-2 in intact cells (IC50s: 2.2 μg/mL and 1.3 μg/mL, respectively)[1].
In vivo
Naproxen is shown to inhibit the time-courses of pain, fever, and PGE2 with similar potencies (IC50=27, 40, 13 μM). Naproxen exerts an anti-inflammatory and antifibrotic effect in the mouse model of bleomycin-induced lung fibrosis. Naproxen also downregulates TGF-β levels and Smad3/4 complex formation [2][3].
AliasMX 1094, LT-NS 001
Chemical Properties
Molecular Weight336.4
FormulaC17H20O5S
Cas No.385800-16-8
Relative Density.1.238 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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