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Neostigmine bromide

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Purity:98.02%

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COA HNMR HPLC

Neostigmine bromide

Catalog No. T1624Cas No. 114-80-7

Neostigmine bromide is a cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike PHYSOSTIGMINE, does not cross the blood-brain barrier.

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Product Introduction

Bioactivity

Description	Neostigmine bromide is a cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike PHYSOSTIGMINE, does not cross the blood-brain barrier.
Alias	Neoserine bromide, Eustigmin bromide

Chemical Properties

Molecular Weight	303.2
Formula	C12H19BrN2O2
Cas No.	114-80-7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 38 mg/mL (125.33 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2982 mL	16.4908 mL	32.9815 mL	164.9077 mL
5 mM	0.6596 mL	3.2982 mL	6.5963 mL	32.9815 mL
10 mM	0.3298 mL	1.6491 mL	3.2982 mL	16.4908 mL
20 mM	0.1649 mL	0.8245 mL	1.6491 mL	8.2454 mL
50 mM	0.0660 mL	0.3298 mL	0.6596 mL	3.2982 mL
100 mM	0.0330 mL	0.1649 mL	0.3298 mL	1.6491 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc