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NLRP3-IN-16
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Catalog No. T73015Cas No. 2906872-59-9
NLRP3-IN-16 is a potent, selective inhibitor of the NLRP3 inflammasome, effectively reducing IL-1β release with an IC50 of 0.065 μM, and is primarily utilized in inflammation research [1].
NLRP3-IN-16
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Catalog No. T73015Cas No. 2906872-59-9
NLRP3-IN-16 is a potent, selective inhibitor of the NLRP3 inflammasome, effectively reducing IL-1β release with an IC50 of 0.065 μM, and is primarily utilized in inflammation research [1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,520 | 6-8 weeks | |
| 50 mg | $1,980 | 6-8 weeks | |
| 100 mg | $2,500 | 6-8 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | NLRP3-IN-16 is a potent, selective inhibitor of the NLRP3 inflammasome, effectively reducing IL-1β release with an IC50 of 0.065 μM, and is primarily utilized in inflammation research [1]. |
| In vitro | NLRP3-IN-16 (Compound 12d) inhibits the release of IL-1β with an IC50 of 0.065 μM, as measured by ELISA [1]. At a concentration of 2 μM, for 3 hours, it suppresses the secretion of IL-1β (p17) and caspase-1 (p20) in mouse peritoneal macrophages (PM) [1]. Additionally, NLRP3-IN-16 impedes the formation of the NLRP3 inflammasome complex by inhibiting ASC oligomerization [1]. It exhibits metabolic stability in human and mouse liver microsomes, with a half-life (T 1/2) of 223.5 minutes and an intrinsic clearance (Cl int) of 6.2 μL/min/mg [1]. |
| In vivo | NLRP3-IN-16 (Compound 5j) exhibited anti-inflammatory effects in a sepsis mouse model when administered at a dose of 50 mg/kg intraperitoneally [1]. |
| Molecular Weight | 419.47 |
| Formula | C25H25NO5 |
| Cas No. | 2906872-59-9 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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