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NVP-BSK805
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NVP-BSK805
Catalog No. T5049Cas No. 1092499-93-8
NVP-BSK805 (BSK 805) is an ATP-competitive JAK2 inhibitor.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $57 | 7-10 days | |
| 5 mg | $133 | 7-10 days | |
| 10 mg | $220 | 7-10 days | |
| 25 mg | $432 | 7-10 days |
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | NVP-BSK805 (BSK 805) is an ATP-competitive JAK2 inhibitor. |
| In vitro | GI50 of <100 nM. NVP-BSK805 blocks the STAT5 phosphorylation at ≥100 nM concentrations, and shows a bias for JAK2 over JAK1 and JAK3 inhibition in the JAK2V617F-mutant cell lines. NVP-BSK805 (5 μM) improves P-gp inhibitory activity. NVP-BSK805 increases sensitization of drug-resistant KBV20C cancer cells to VIC treatment at 10 μM, and such an effect is more effective than a 5 μM dose. |
| In vivo | NVP-BSK805 (150 mg/kg, p.o.) blocks STAT5 phosphorylation, splenomegaly, and leukemic cell spreading in a Ba/F3 JAK2V617F cell-driven mouse model. NVP-BSK805 (50, 75, and 100 mg/kg, p.o.) also suppresses rhEpo-mediated polycythemia and splenomegaly in BALB/c mice. |
| Alias | NVP-BSK805 2HCl, BSK 805 |
| Molecular Weight | 490.55 |
| Formula | C27H28F2N6O |
| Cas No. | 1092499-93-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||
| Solubility Information | DMSO: 10mM | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
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