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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $397 | In Stock | |
2 mg | $595 | In Stock |
Description | OSMI-3 is a potent and cell-permeable inhibitor of O-GlcNAc transferase (OGT) for the study of cancer and cardiovascular disease. |
In vitro | Treatment with OSMI-3 (Compound 2b) at concentrations ranging from 20 to 50 μM for durations of 4 to 24 hours in HCT116 cells significantly decreases O-GlcNAc levels, demonstrating more sustained cellular effects compared to OSMI-2[1].In cells treated with OSMI-3 (Compound 2b), there is an observable decrease in HCF-1 cleavage products and an increase in uncleaved HCF-1. Given that OGT knockdown is known to reduce cell proliferation, the impact of OSMI-3 on cell growth over 96 hours is monitored. Although there is no evidence of apoptosis, a reduction in cell growth over time is evident, consistent with the results observed with OGT knockdown[1]. |
Molecular Weight | 669.77 |
Formula | C32H35N3O9S2 |
Cas No. | 2260791-13-5 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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