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OSMI-3
🥰Excellent
Catalog No. T12327Cas No. 2260791-13-5
OSMI-3 is a potent and cell-permeable inhibitor of O-GlcNAc transferase (OGT) for the study of cancer and cardiovascular disease.
OSMI-3
🥰Excellent
Purity: 99.08%
Catalog No. T12327Cas No. 2260791-13-5
OSMI-3 is a potent and cell-permeable inhibitor of O-GlcNAc transferase (OGT) for the study of cancer and cardiovascular disease.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $397 | In Stock | |
| 5 mg | $949 | In Stock | |
| 10 mg | $1,290 | In Stock | |
| 25 mg | $1,890 | In Stock | |
| 50 mg | $2,580 | In Stock |
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Purity:99.08%
ee:100%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | OSMI-3 is a potent and cell-permeable inhibitor of O-GlcNAc transferase (OGT) for the study of cancer and cardiovascular disease. |
| In vitro | Treatment with OSMI-3 (Compound 2b) at concentrations ranging from 20 to 50 μM for durations of 4 to 24 hours in HCT116 cells significantly decreases O-GlcNAc levels, demonstrating more sustained cellular effects compared to OSMI-2[1].In cells treated with OSMI-3 (Compound 2b), there is an observable decrease in HCF-1 cleavage products and an increase in uncleaved HCF-1. Given that OGT knockdown is known to reduce cell proliferation, the impact of OSMI-3 on cell growth over 96 hours is monitored. Although there is no evidence of apoptosis, a reduction in cell growth over time is evident, consistent with the results observed with OGT knockdown[1]. |
| Molecular Weight | 669.77 |
| Formula | C32H35N3O9S2 |
| Cas No. | 2260791-13-5 |
| Smiles | [C@@H](C(N(CC1=CC=CS1)CC(OCC)=O)=O)(NS(=O)(=O)C=2C=C3C(=CC2)NC(=O)C=C3)C4=C(OCCCC(OCC)=O)C=CC=C4 |
| Relative Density. | 1.336 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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