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OXA-11
🥰Excellent
Catalog No. T28277Cas No. 1257994-15-2
Alias OXA11, FAK-IN-16
OXA-11 (FAK-IN-16) is an orally active, selective focal adhesion kinase (FAK) inhibitor with antitumor activity. It inhibits FAK phosphorylation at tyrosine 397 in a dose-dependent manner and suppresses TOV21G tumor growth. It is used in cancer research.
OXA-11
🥰Excellent
Purity: 99.20%
Catalog No. T28277Alias OXA11, FAK-IN-16Cas No. 1257994-15-2
OXA-11 (FAK-IN-16) is an orally active, selective focal adhesion kinase (FAK) inhibitor with antitumor activity. It inhibits FAK phosphorylation at tyrosine 397 in a dose-dependent manner and suppresses TOV21G tumor growth. It is used in cancer research.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $1,590 | In Stock | |
| 5 mg | $3,200 | In Stock | |
| 10 mg | $4,290 | In Stock |
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Purity:99.20%
ee:100%
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.Product Introduction
Bioactivity
Chemical Properties
| Description | OXA-11 (FAK-IN-16) is an orally active, selective focal adhesion kinase (FAK) inhibitor with antitumor activity. It inhibits FAK phosphorylation at tyrosine 397 in a dose-dependent manner and suppresses TOV21G tumor growth. It is used in cancer research. |
| Targets&IC50 | FAK:1.2 pM |
| In vitro | OXA-11 is a selective photophosphorylation inhibitor of plaque adhesion kinase (FAK) with an IC50 of 1.2 pM. In 3-D culture, OXA-11 inhibited the proliferation of tumor cells, with EC50 of 9 nM in TOV21G cells and 0.3 nM in IGROV1 cells, and promoted apoptosis of tumor cells, with EC50 of 31 nM in TOV21G cells. The EC50 of IGROV1 cells was 0.5 nM. [1] |
| In vivo | Intragastric administration of OXA-11 (40-120 mg/kg, soluble in 20% Trappsol) can reduce tumor vascular distribution and infiltration in mice, and when administered together with anti-VEGFR-2 antibody DC101, can reduce pancreatic neuroendocrine tumor metastasis in RIP-Tag2 mice. [1] |
| Alias | OXA11, FAK-IN-16 |
| Molecular Weight | 759.8 |
| Formula | C37H49F3N7O5P |
| Cas No. | 1257994-15-2 |
| Smiles | N(C1=C2C(=C(C=C1)[C@H]3CC[C@@H](CC3)N4CCN(C)CC4)CN(C)C2=O)C=5C(C(F)(F)F)=CN=C(NC6=C(OC)C=C(CP(OCC)(OCC)=O)C=C6)N5 |
| Relative Density. | 1.299 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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