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Ifebemtinib FA
🥰Excellent
Catalog No. T64167L
Alias BI-853520 FA（1227948-82-4 Free base)
Ifebemtinib FA (BI-853520 FA) is an orally active and potent inhibitor of adhesion patch kinase (FAK) with anticancer and antiproliferative activity for the study of ovarian and lung cancer.
Ifebemtinib FA
🥰Excellent
Purity: 99.62%
Catalog No. T64167LAlias BI-853520 FA（1227948-82-4 Free base)
Ifebemtinib FA (BI-853520 FA) is an orally active and potent inhibitor of adhesion patch kinase (FAK) with anticancer and antiproliferative activity for the study of ovarian and lung cancer.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $163 | In Stock | |
| 5 mg | $413 | In Stock | |
| 10 mg | $690 | In Stock | |
| 25 mg | $1,290 | In Stock | |
| 50 mg | $1,730 | In Stock | |
| 100 mg | $2,330 | In Stock |
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Ifebemtinib (BI-853520) is an orally active and potent inhibitor of adhesion plaque kinase (FAK) (IC50=1 nM) with anti-tumour activity that inhibits globule formation and in situ tumour growth in malignant pleural mesotheliomas, and may be useful for the study of breast and ovarian cancer.
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Purity:99.62%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Ifebemtinib FA (BI-853520 FA) is an orally active and potent inhibitor of adhesion patch kinase (FAK) with anticancer and antiproliferative activity for the study of ovarian and lung cancer. |
| Targets&IC50 | FAK:1 nM, FES:1040 nM, FER:900 nM |
| In vitro | The compound Ifebemtinib FA (BI-853520 FA) inhibits cancer cell growth at concentrations ranging from 0 to 3 μM for 2 hours[2]. Repression of tumor cell proliferation and invasion in 3D culture is observed with Ifebemtinib FA at concentrations from 0 to 30 μM for 4-6 days[1]. Additionally, Ifebemtinib FA represses Y397-FAK autophosphorylation at concentrations ranging from 0 to 10 μM for 24 hours, and at a concentration of 0.1 μM for 96 hours, Ifebemtinib FA demonstrates a fast and potent inhibition of FAK in this highly metastatic murine breast cancer cell line[3]. |
| In vivo | The oral gavage treatment of Ifebemtinib FA (BI-853520 FA) at a dose of 50 mg/kg once daily for 0-8 weeks significantly suppresses the primary tumor growth of all three cell lines in vivo[3]. |
| Alias | BI-853520 FA（1227948-82-4 Free base) |
| Molecular Weight | 634.58 |
| Formula | C29H30F4N6O6 |
| Smiles | O=C(C1=C(F)C=C(NC2=NC=C(C(F)(F)F)C(OC3=CC=CC4=C3C(N(C4)C)=O)=N2)C(OC)=C1)NC5CCN(CC5)C.[H]C(O)=O |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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