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Pack Size | Price | Availability | Quantity |
---|---|---|---|
10 mg | $43 | In Stock | |
25 mg | $63 | In Stock | |
50 mg | $75 | In Stock | |
100 mg | $139 | In Stock | |
200 mg | $198 | In Stock | |
500 mg | $349 | In Stock | |
1 mL x 10 mM (in DMSO) | $40 | In Stock |
Description | Y15 (1,2,4,5-Benzenetetramine tetrahydrochlor) is a potent and specificsmall-molecule FAK scaffolding inhibitor that inhibits its autophosphorylation activity, blocks tumor growth. |
In vitro | Y15 inhibited viability in ?thyroid cancer cell lines in a dose-dependent manner[1]. |
Cell Research | Apoptosis assay was done with PE Annexin V Apoptosis Detection Kit (BD) to identify apoptotic nuclei.?One hundred millimeter plates were seeded with TPC1, K1, BCPAP and TT cells at a concentration of 1 × 10^6 cells in normal growth media.?After overnight incubation, plates were treated with one of several doses of Y15 or left untreated.?After another 24 h of incubation, cells were collected with trypsin, and following centrifugation, were washed with 1× PBS.?Again, cells were centrifuged, PBS was removed and cells were resuspended in binding buffer and filtered through BD mesh tubes.?Annexin V and 7-AAD were added to the solution, vortexed and incubated for 15 minutes in the dark.?Binding buffer was added and the cells were analyzed by flow cytometry within 1 hour. |
Alias | 1,2,4,5-Benzenetetramine tetrahydrochlor, FAK Inhibitor 14 |
Molecular Weight | 284.01 |
Formula | C6H14Cl4N4 |
Cas No. | 4506-66-5 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | H2O: 59 mg/mL (207.74 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
H2O
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