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Ifebemtinib

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Purity:99.82%

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COA HNMR HPLC LCMS

Ifebemtinib

Catalog No. T64167Cas No. 1227948-82-4

Ifebemtinib (BI-853520) is an orally active and potent inhibitor of adhesion plaque kinase (FAK) (IC50=1 nM) with anti-tumour activity that inhibits globule formation and in situ tumour growth in malignant pleural mesotheliomas, and may be useful for the study of breast and ovarian cancer.

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Pack Size	Price	Availability
1 mg	$165	In Stock
5 mg	$413	In Stock
10 mg	$579	In Stock
25 mg	$928	In Stock
50 mg	$1,190	In Stock
100 mg	$1,460	In Stock

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Product Introduction

Bioactivity

Description	Ifebemtinib (BI-853520) is an orally active and potent inhibitor of adhesion plaque kinase (FAK) (IC50=1 nM) with anti-tumour activity that inhibits globule formation and in situ tumour growth in malignant pleural mesotheliomas, and may be useful for the study of breast and ovarian cancer.
Targets&IC50	FAK:1 nM, FES:1040 nM, FER:900 nM
In vitro	4T1, Py2T, and Py2T-LT cells were exposed to increasing concentrations of BI-853520 (0, 0.1, 0.5, 1, 5, and 10 μM for 4T1 cells; 1, 3, and 10 μM for Py2T and Py2T-LT cells) for 24 hours. The results demonstrate that BI-853520 reduces Y397-FAK phosphorylation in a dose-dependent and time-dependent manner[2].
In vivo	In PC-3 cells, BI-853520（Ifebemtinib；0-3 μM; 2 h) resulted in a concentration-dependent reduction of the signal, with a median EC50 value of 1 nM[2].
Alias	IN-10018, BI-853520

Chemical Properties

Molecular Weight	588.55
Formula	C28H28F4N6O4
Cas No.	1227948-82-4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 50 mg/mL (84.89 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6991 mL	8.4955 mL	16.9909 mL	84.9545 mL
5 mM	0.3398 mL	1.6991 mL	3.3982 mL	16.9909 mL
10 mM	0.1699 mL	0.8495 mL	1.6991 mL	8.4955 mL
20 mM	0.0850 mL	0.4248 mL	0.8495 mL	4.2477 mL
50 mM	0.0340 mL	0.1699 mL	0.3398 mL	1.6991 mL

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Ifebemtinib

Ifebemtinib

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