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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $165 | In Stock | |
5 mg | $413 | In Stock | |
10 mg | $579 | In Stock | |
25 mg | $928 | In Stock | |
50 mg | $1,190 | In Stock | |
100 mg | $1,460 | In Stock |
Description | Ifebemtinib (BI-853520) is an orally active and potent inhibitor of adhesion plaque kinase (FAK) (IC50=1 nM) with anti-tumour activity that inhibits globule formation and in situ tumour growth in malignant pleural mesotheliomas, and may be useful for the study of breast and ovarian cancer. |
Targets&IC50 | FAK:1 nM, FES:1040 nM, FER:900 nM |
In vitro | 4T1, Py2T, and Py2T-LT cells were exposed to increasing concentrations of BI-853520 (0, 0.1, 0.5, 1, 5, and 10 μM for 4T1 cells; 1, 3, and 10 μM for Py2T and Py2T-LT cells) for 24 hours. The results demonstrate that BI-853520 reduces Y397-FAK phosphorylation in a dose-dependent and time-dependent manner[2]. |
In vivo | In PC-3 cells, BI-853520(Ifebemtinib;0-3 μM; 2 h) resulted in a concentration-dependent reduction of the signal, with a median EC50 value of 1 nM[2]. |
Alias | IN-10018, BI-853520 |
Molecular Weight | 588.55 |
Formula | C28H28F4N6O4 |
Cas No. | 1227948-82-4 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 50 mg/mL (84.89 mM) | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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