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PBRM (17β-HSD1-IN-2) is a selective covalent inhibitor of 17β-HSD1, used in breast cancer and endometriosis research.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $775 | In Stock | |
5 mg | $1,590 | In Stock | |
10 mg | $2,170 | In Stock | |
25 mg | $3,230 | In Stock | |
50 mg | $4,200 | In Stock |
Description | PBRM (17β-HSD1-IN-2) is a selective covalent inhibitor of 17β-HSD1, used in breast cancer and endometriosis research. |
In vitro | PBRM (0.1-10 μM) inhibited the formation of 5-diol from DHEA by T-47D cells in a dose-dependent manner with IC50 = 0.77 μM. [1] |
In vivo | PBRM (15 mg/kg orally) effectively reversed T-47D tumor growth. [1] The half-life of PBRM (14.7 mg/kg subcutaneous injection) in mice was T1/2= 3.4 hours, clearance CL = 2088 mL/h kg, distribution volume Vz = 10.3 L/kg, absolute bioavailability F = 65%. [2] |
Alias | 17β-HSD1-IN-2 |
Molecular Weight | 496.48 |
Formula | C28H34BrNO2 |
Cas No. | 1318265-18-7 |
Smiles | C[C@@]12[C@]([C@]3([C@@](C=4C(CC3)=CC(CCBr)=CC4)(CC1)[H])[H])(C[C@H](CC5=CC(C(N)=O)=CC=C5)[C@@H]2O)[H] |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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