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PCAF-IN-1
🥰Excellent
Catalog No. T60762Cas No. 2439194-86-0
PCAF-IN-1 is a highly selective PCAF (p300/CBP-associated factor) inhibitor with potential anti-tumor, anti-inflammatory, and anti-heart disease effects. Inhibition of PCAF attenuates cardiac remodeling after myocardial infarction, reduces polarization of M1-type macrophages, and attenuates autoimmune arthritis.
PCAF-IN-1
🥰Excellent
Catalog No. T60762Cas No. 2439194-86-0
PCAF-IN-1 is a highly selective PCAF (p300/CBP-associated factor) inhibitor with potential anti-tumor, anti-inflammatory, and anti-heart disease effects. Inhibition of PCAF attenuates cardiac remodeling after myocardial infarction, reduces polarization of M1-type macrophages, and attenuates autoimmune arthritis.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $75 | In Stock | |
| 5 mg | $129 | In Stock | |
| 10 mg | $216 | In Stock | |
| 25 mg | $439 | In Stock | |
| 50 mg | $646 | In Stock | |
| 100 mg | $918 | In Stock | |
| 200 mg | $1,250 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | PCAF-IN-1 is a highly selective PCAF (p300/CBP-associated factor) inhibitor with potential anti-tumor, anti-inflammatory, and anti-heart disease effects. Inhibition of PCAF attenuates cardiac remodeling after myocardial infarction, reduces polarization of M1-type macrophages, and attenuates autoimmune arthritis. |
| In vitro | Methods: Hepatocellular carcinoma (HePG-2), breast cancer (MCF-7), prostate cancer (PC3), and colorectal cancer (HCT-116) cells were treated with PCAF-IN-1 (10 μM, 72 hours), and cell viability was measured by MTT. Results: PCAF-IN-1 showed the strongest antitumor activity against human cancer cell lines. [1]. |
| Molecular Weight | 310.74 |
| Formula | C15H11ClN6 |
| Cas No. | 2439194-86-0 |
| Smiles | ClC=1C=CC(=CC1)C2=NN=C3C=4C=CC=CC4C(=NN)NN23 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO: 0.1 mg/mL (0.32 mM), Sonication and heating are recommended. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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