PCAF-IN-1 is a antitumor agents used in tumor treatment research. PCAF-IN-1 is a highly selective inhibitor of PCAF [1].

PCAF-IN-1 (Compound 32), at a concentration of 10 µM over 72 hours, demonstrates significant antitumor efficacy across various human cancer cell lines, including hepatocellular carcinoma (HePG-2), breast cancer (MCF-7), prostate cancer (PC3), and colorectal carcinoma (HCT-116). The compound effectively inhibited these cancer cells, with IC50 values of 4.89 µM for HePG-2, 6.18 µM for MCF-7, 9.71 µM for PC3, and 3.76 µM for HCT-116, showcasing its potent anti-cancer activities in a Cell Cytotoxicity Assay.