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PD 168368

PD 168368
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Purity:98.44%
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PD 168368

Catalog No. T8691Cas No. 204066-82-0
PD 168368 is a novel, potent, competitive and selective nonpeptide neuromodulin B receptor (NMB-R) antagonist with inhibitory effects on the gastrin-releasing peptide receptor (GRPR).PD 168368 is a potent mixed agonist of FPR1/FPR2/FPR3.
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Pack SizePriceAvailabilityQuantity
1 mg$99In Stock
25 mgInquiry8-10 weeks
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Product Introduction

Bioactivity
Description
PD 168368 is a novel, potent, competitive and selective nonpeptide neuromodulin B receptor (NMB-R) antagonist with inhibitory effects on the gastrin-releasing peptide receptor (GRPR).PD 168368 is a potent mixed agonist of FPR1/FPR2/FPR3.
In vitro
PD 168368 exhibits high activity and induces [Ca2+]I release in human neutrophils, with EC50 values in the nanomolar range[3].
In the human breast cancer cell line MDA-MB-231, PD 168368 suppresses migration and invasion. It also reduces epithelial-mesenchymal transition (EMT) by upregulating E-cadherin and downregulating vimentin. At a concentration of 5 μM, PD 168368 inhibits migration and invasiveness in breast cancer cells[4].
Furthermore, at a concentration of 10 μM, PD 168368 suppresses the activation of the mTOR/p70S6K/4EBP1 and AKT/GSK-3β pathways in breast cancer cells[4].
In vivo
In mice, PD 168368 potently inhibits the in vivo metastasis of breast cancer. Administered at a dose of 1.2 mg/kg through intraperitoneal injection for 30 days, PD 168368 effectively inhibits breast cancer metastasis[4].
AliasPD168368
Chemical Properties
Molecular Weight554.64
FormulaC31H34N6O4
Cas No.204066-82-0
Storage & Solubility Information
Storagestore at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 20 mg/mL(36.06 mM)
DMF: 5 mg/mL(9.01 mM)
Solution Preparation Table
DMSO/DMF
1mg5mg10mg50mg
1 mM1.8030 mL9.0149 mL18.0297 mL90.1486 mL
5 mM0.3606 mL1.8030 mL3.6059 mL18.0297 mL
DMSO
1mg5mg10mg50mg
10 mM0.1803 mL0.9015 mL1.8030 mL9.0149 mL
20 mM0.0901 mL0.4507 mL0.9015 mL4.5074 mL
50 mM0.0361 mL0.1803 mL0.3606 mL1.8030 mL
100 mM0.0180 mL0.0901 mL0.1803 mL0.9015 mL

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