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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $56 | In Stock | |
2 mg | $84 | In Stock | |
5 mg | $147 | In Stock | |
10 mg | $228 | In Stock | |
25 mg | $438 | In Stock | |
1 mL x 10 mM (in DMSO) | $223 | In Stock |
Description | Kuwanon H, and possibly kuwanon G also, are specific antagonists for the gastrin-releasing peptide (GRP) -preferring receptor and can be useful for studying the physiological and pathological role of GRP. |
In vitro | Kuwanon G and H, isolated from the methanol extract of Morus bombycis, inhibited specific binding of [125I]gastrin-releasing peptide (GRP) to GRP-preferring receptors in murine Swiss 3T3 fibroblasts with Ki values of 470 and 290 nM, respectively. Kuwanon H was one order of magnitude less potent for inhibiting [125I]bombesin binding to neuromedin B (NMB)-preferring receptors in rat esophagus membranes. This compound antagonized bombesin-induced increases in the cytosolic free calcium concentration and GRP-induced DNA synthesis in Swiss 3T3 cells. |
Molecular Weight | 760.82 |
Formula | C45H44O11 |
Cas No. | 76472-87-2 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 50 mg/mL (65.72 mM) | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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