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PD-L1-IN-2
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PD-L1-IN-2
Catalog No. T78053Cas No. 2894733-91-4
PD-L1-IN-2, a Naamidine J derivative, serves as a promising antineoplastic immunomodulator by hindering PD-L1 activity. In vivo studies indicate that it suppresses PD-L1 expression and amplifies tumor-infiltrating T-cell response, thus exerting anticancer effects. This compound is particularly utilized in the investigation of colorectal cancer [1].
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | Inquiry | 8-10 weeks | |
| 50 mg | Inquiry | 8-10 weeks |
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View MoreInhibitors Related to "PD-L1-IN-2"
PD-L1-IN-3
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BMS-1
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BMS-1 (PD-1/PD-L1 inhibitor 1) is an inhibitor of the PD1-PD-L1 protein-protein interaction. It also acts as an immunomodulator. Programmed death ligand 1 (PD-L1) is a protein in humans that is encoded by the CD274 gene and the upregulation of PD-L1 allows Ys to evade the host immune system. High tumor expression of PD-L1 was associated with increased tumor aggressiveness and a 4.5-fold increased risk of death.
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CitedPD-1/PD-L1-IN-9
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PD-1/PD-L1-IN-9, with an IC50 of 3.8 nM, is a potent and orally active inhibitor of the PD-1/PD-L1 interaction. It enhances the immune cells' ability to kill tumor cells and demonstrates significant antitumor activity in vivo in a CT26 mouse model.
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CitedLSD1-IN-27
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LSD1-IN-27 is a potent LSD1 inhibitor with an IC50 value of 13 nM.LSD1-IN-27 inhibited the stemness and migration of gastric cancer cells.LSD1-IN-27 inhibited the expression of PD-L1 in BGC-823 and MFC cells.LSD1-IN-27 potentiated the T-cell immune response against gastric cancer.
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PD-1-IN-22
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PD-1-IN-22 is a potent inhibitor of the programmed cell death-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) interaction, with an IC50 of 92.3 nM.
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LSD1-IN-24
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | PD-L1-IN-2, a Naamidine J derivative, serves as a promising antineoplastic immunomodulator by hindering PD-L1 activity. In vivo studies indicate that it suppresses PD-L1 expression and amplifies tumor-infiltrating T-cell response, thus exerting anticancer effects. This compound is particularly utilized in the investigation of colorectal cancer [1]. |
| In vitro | PD-L1-IN-2 (compound 11c) has an IC50 value of 31.7 μM against RKO cells [1]. In concentrations of 0-10 μM and over 0-24 hours, PD-L1-IN-2 inhibits PD-L1 expression in RKO cells dose- and time-dependently [1]. PD-L1-IN-2 also enhances PD-L1 protein turnover, as shown by an accelerated PD-L1 turnover rate in treated cells compared to untreated cells in a CHX pulse-chase assay [1]. |
| In vivo | Administered intraperitoneally at 25/50 mg/kg once daily for 16 days, PD-L1-IN-2 (compound 11c) resulted in tumor size reduction, with the 50 mg/kg group showing a 45% inhibition rate and significantly lower average tumor weight compared to the PBS group [1]. |
| Molecular Weight | 586.68 |
| Formula | C33H38N4O6 |
| Cas No. | 2894733-91-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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