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Pack Size | Price | Availability | Quantity |
---|---|---|---|
200 mg | $29 | In Stock | |
1 mL x 10 mM (in DMSO) | $50 | In Stock |
Description | Phenyl-β-D-glucopyranoside (PHENYL-B-D-GLUCOPYRANOSIDE) is a component of Phellodendron amurense with anti-cancer and anti-inflammatory activities. |
In vitro | Phenyl-β-D-Glucopyranoside Exhibits Anti-inflammatory Activity in Lipopolysaccharide-Activated RAW 264.7 Cells. Phenyl-β-D-glucopyranoside not only inhibited nitric oxide (NO) production but also significantly inhibited the expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2) without inducing cytotoxicity. Phenyl-β-D-glucopyranoside also attenuated proinflammatory cytokines, including tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and other inflammation-related genes, such as IL-6 in a concentration-dependent manner. Furthermore, phenyl-β-D-glucopyranoside abolished increased adhesion, ninjurin 1 (Ninj1) expression, and matrix metalloproteinase (MMP) activity induced by endotoxin treatment. Finally, phenyl-β-D-glucopyranoside inhibited the nuclear translocation of nuclear factor-κB (NF-κB), which is one of the most important transcription factors involved in the inflammatory process. |
Alias | PHENYL-B-D-GLUCOPYRANOSIDE |
Molecular Weight | 256.25 |
Formula | C12H16O6 |
Cas No. | 1464-44-4 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | H2O: soluble DMSO: 60 mg/ml (234.15 mM) ![]() | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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