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PKUMDL-LC-101-D04
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PKUMDL-LC-101-D04
Catalog No. T36935Cas No. 2143896-83-5
PKUMDL-LC-101-D04 is a potent allosteric activator of glutathione peroxidase 4 (GPX4), a regulator of iron death. GPX4 activity was increased to 150% of control levels when used at a concentration of 20 μM in a cell-free assay, and at a concentration of 61 μM in wild-type, but not Gpx4-/-, mouse embryonic fibroblast (MEF) extracts.PKUMDL-LC-101-D04 (200 μM) reduced cholesterol peroxide-induced MEF death.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $80 | In Stock | |
| 5 mg | $289 | In Stock | |
| 10 mg | $428 | In Stock | |
| 25 mg | $686 | In Stock | |
| 50 mg | $969 | In Stock | |
| 100 mg | $1,280 | In Stock | |
| 500 mg | $2,620 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | PKUMDL-LC-101-D04 is a potent allosteric activator of glutathione peroxidase 4 (GPX4), a regulator of iron death. GPX4 activity was increased to 150% of control levels when used at a concentration of 20 μM in a cell-free assay, and at a concentration of 61 μM in wild-type, but not Gpx4-/-, mouse embryonic fibroblast (MEF) extracts.PKUMDL-LC-101-D04 (200 μM) reduced cholesterol peroxide-induced MEF death. |
| In vitro | PKUMDL-LC-101-D04 (20 μM) increases GPX4 activity to 150% of control levels when used at a concentration of 20 μM in a cell-free assay.[1] PKUMDL-LC-101-D04 (200 μM) also reduces cholesterol hydroperoxide-induced MEF death.[1] |
| Alias | GPX4-Activator-1d4, PKUMDL-LC-101-D04 |
| Molecular Weight | 378.94 |
| Formula | C14H23ClN4O2S2 |
| Cas No. | 2143896-83-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 225.0 mg/mL (593.8 mM) | |||||||||||||||||||||||||||||||||||
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