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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $80 | In Stock | |
5 mg | $289 | In Stock | |
10 mg | $428 | In Stock | |
25 mg | $686 | In Stock | |
50 mg | $969 | In Stock | |
100 mg | $1,280 | In Stock | |
500 mg | $2,620 | In Stock |
Description | PKUMDL-LC-101-D04 is a potent allosteric activator of glutathione peroxidase 4 (GPX4), a regulator of iron death. GPX4 activity was increased to 150% of control levels when used at a concentration of 20 μM in a cell-free assay, and at a concentration of 61 μM in wild-type, but not Gpx4-/-, mouse embryonic fibroblast (MEF) extracts.PKUMDL-LC-101-D04 (200 μM) reduced cholesterol peroxide-induced MEF death. |
In vitro | PKUMDL-LC-101-D04 (20 μM) increases GPX4 activity to 150% of control levels when used at a concentration of 20 μM in a cell-free assay.[1] PKUMDL-LC-101-D04 (200 μM) also reduces cholesterol hydroperoxide-induced MEF death.[1] |
Alias | GPX4-Activator-1d4, PKUMDL-LC-101-D04 |
Molecular Weight | 378.94 |
Formula | C14H23ClN4O2S2 |
Cas No. | 2143896-83-5 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 225.0 mg/mL (593.8 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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