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JKE-1674
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JKE-1674
Catalog No. T37314Cas No. 2421119-60-8
JKE-1674 is an inhibitor of glutathione peroxidase 4 (GPX4). JKE-1674 is an active metabolite of the GPX4 inhibitor ML-210.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $48 | In Stock | |
| 5 mg | $113 | In Stock | |
| 10 mg | $183 | In Stock | |
| 25 mg | $372 | In Stock | |
| 50 mg | $597 | In Stock | |
| 100 mg | $955 | In Stock | |
| 200 mg | $1,280 | In Stock | |
| 500 mg | $1,890 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $137 | In Stock |
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ML-210
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ML-210 (CID 49766530) is a selective RAS and covalent glutathione peroxidase 4 (GPX4) inhibitor(GPX4, EC50 : 30 nM), with anti-cancer activity
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CitedRSL3
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RSL3 (RSL3 1S) is an inhibitor of GPX4, and inhibits system xc- that blocks GSH synthesis (IC50=100 nM). RSL3 is a VDAC-independent activator of iron death that is selective for tumor cells carrying oncogenic RAS.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | JKE-1674 is an inhibitor of glutathione peroxidase 4 (GPX4). JKE-1674 is an active metabolite of the GPX4 inhibitor ML-210. |
| In vitro | JKE-1674 reduces the viability of LOX-IMVI cancer cells with an EC50 of 0.03 μM and in a panel of additional cancer cell lines. JKE-1674 is completely rescued by ferroptosis inhibitors[1]. |
| In vivo | JKE-1674 (50?mg/kg; p.o.) could be detected in the serum of mice dosed orally with the compound[2]. |
| Molecular Weight | 451.3 |
| Formula | C20H20Cl2N4O4 |
| Cas No. | 2421119-60-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||
| Solubility Information | DMSO: 13 mg/mL (28.81 mM)  | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
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