Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty

Plx-4032

🥰Excellent
Catalog No. T8654Cas No. 1029872-54-5
Alias Vemurafenib

Plx-4032 (Vemurafenib) is a small-molecule B-Raf inhibitor for the potential treatment of malignant melanoma.

Plx-4032

Plx-4032

🥰Excellent
Purity: 99.94%
Catalog No. T8654Alias VemurafenibCas No. 1029872-54-5
Plx-4032 (Vemurafenib) is a small-molecule B-Raf inhibitor for the potential treatment of malignant melanoma.
Pack SizePriceAvailabilityQuantity
10 mg47 €In Stock
50 mg68 €In Stock
100 mg95 €In Stock
200 mg171 €In Stock
500 mg290 €In Stock
1 mL x 10 mM (in DMSO)47 €In Stock
Bulk & Custom
Add to Cart
Questions
View More

Related Compound Libraries of "Plx-4032"

Select Batch
Purity:99.94%
Contact us for more batch information
Resource Download
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity
Description
Plx-4032 (Vemurafenib) is a small-molecule B-Raf inhibitor for the potential treatment of malignant melanoma.
In vivo
PLX-4032 and its related analogs are highly potent inhibitors of B-Raf activity, with 3-fold selectivity for the V600E mutation over the wild-type kinase.?In preclinical models, PLX-4032 and its analogs inhibited the growth of BRAFV600E-positive melanoma cell lines both in vitro and in vivo[1].
AliasVemurafenib
Chemical Properties
Molecular Weight489.92
FormulaC23H18ClF2N3O3S
Cas No.1029872-54-5
SmilesCCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(cc23)-c2ccc(Cl)cc2)c1F
Relative Density.1.46
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 30 mg/mL (61.23 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.0411 mL10.2057 mL20.4115 mL102.0575 mL
5 mM0.4082 mL2.0411 mL4.0823 mL20.4115 mL
10 mM0.2041 mL1.0206 mL2.0411 mL10.2057 mL
20 mM0.1021 mL0.5103 mL1.0206 mL5.1029 mL
50 mM0.0408 mL0.2041 mL0.4082 mL2.0411 mL

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
%Tween 80
%ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Related Tags: buy Plx-4032 | purchase Plx-4032 | Plx-4032 cost | order Plx-4032 | Plx-4032 chemical structure | Plx-4032 in vivo | Plx-4032 formula | Plx-4032 molecular weight