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Pregnenolone monosulfate sodium salt is the sodium salt form of Pregnenolone monosulfate.Pregnenolone monosulfate is an endogenous neurosteroid, enhances NMDA receptor-mediated synaptic activity and intracellular Ca²⁺ concentrations, activates CREB phosphorylation, activates TRPM3 channels, and may inhibit GABA A receptors.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $30 | In Stock | |
5 mg | $42 | In Stock | |
10 mg | $63 | In Stock | |
25 mg | $113 | In Stock | |
50 mg | $170 | In Stock | |
100 mg | $255 | In Stock |
Description | Pregnenolone monosulfate sodium salt is the sodium salt form of Pregnenolone monosulfate.Pregnenolone monosulfate is an endogenous neurosteroid, enhances NMDA receptor-mediated synaptic activity and intracellular Ca²⁺ concentrations, activates CREB phosphorylation, activates TRPM3 channels, and may inhibit GABA A receptors. |
In vitro | Pregnenolone monosulfate sodium does not alter agonist binding, but only agonist efficacy. Pregnenolone monosulfate sodium may act as a signal-specific negative allosteric modulator that occupies a site distinct from that occupied by the orthosteric ligand. When slices were pretreated with 100 nM Pregnenolone monosulfate sodium, the effects of THC were significantly attenuated (15.1 ± 1.8% inhibition). These effects may be due to Pregnenolone monosulfate sodium's presynaptic actions. Thus, Pregnenolone monosulfate sodium prevented the THC-induced increase in paired-pulse ratio but did not alter the amplitude or decay time of miniature EPSCs. [1] |
In vivo | Pregnenolone monosulfate sodium (2, 4 mg/kg) injected before each dose reduced WIN 55,212-2 intake and lowered breakpoints in a progressive ratio schedule. Pregnenolone monosulfate sodium (2-6 mg/kg) blocked THC-induced food intake in Wistar rats and C57BL/6N mice and attenuated THC-induced memory impairment in mice, but it did not modify these behaviors by itself [1]. |
Alias | 3β-Hydroxy-5-pregnen-20-one monosulfate sodium |
Molecular Weight | 418.52 |
Formula | C21H31NaO5S |
Cas No. | 1852-38-6 |
Smiles | C[C@@]12[C@]3([H])[C@](CC=C1C[C@H](CC2)OS(=O)([O-])=O)([H])[C@@]4([H])[C@](CC3)([C@H](CC4)C(C)=O)C.[Na+] |
Relative Density. | no data available |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 80.00 mg/mL (191.15 mM), Sonication is recommended. H2O: 2.00 mg/mL (4.78 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
H2O/DMSO
DMSO
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