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Pregnenolone monosulfate sodium

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Catalog No. T16574Cas No. 1852-38-6
Alias 3β-Hydroxy-5-pregnen-20-one monosulfate sodium

Pregnenolone monosulfate sodium salt is the sodium salt form of Pregnenolone monosulfate.Pregnenolone monosulfate is an endogenous neurosteroid, enhances NMDA receptor-mediated synaptic activity and intracellular Ca²⁺ concentrations, activates CREB phosphorylation, activates TRPM3 channels, and may inhibit GABA A receptors.

Pregnenolone monosulfate sodium

Pregnenolone monosulfate sodium

🥰Excellent
Purity: 99.763%
Catalog No. T16574Alias 3β-Hydroxy-5-pregnen-20-one monosulfate sodiumCas No. 1852-38-6
Pregnenolone monosulfate sodium salt is the sodium salt form of Pregnenolone monosulfate.Pregnenolone monosulfate is an endogenous neurosteroid, enhances NMDA receptor-mediated synaptic activity and intracellular Ca²⁺ concentrations, activates CREB phosphorylation, activates TRPM3 channels, and may inhibit GABA A receptors.
Pack SizePriceAvailabilityQuantity
2 mg$30 In Stock
5 mg$42 In Stock
10 mg$63 In Stock
25 mg$113 In Stock
50 mg$170 In Stock
100 mg$255 In Stock
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Purity:99.763%
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Product Introduction

Bioactivity
Description
Pregnenolone monosulfate sodium salt is the sodium salt form of Pregnenolone monosulfate.Pregnenolone monosulfate is an endogenous neurosteroid, enhances NMDA receptor-mediated synaptic activity and intracellular Ca²⁺ concentrations, activates CREB phosphorylation, activates TRPM3 channels, and may inhibit GABA A receptors.
In vitro
Pregnenolone monosulfate sodium does not alter agonist binding, but only agonist efficacy. Pregnenolone monosulfate sodium may act as a signal-specific negative allosteric modulator that occupies a site distinct from that occupied by the orthosteric ligand. When slices were pretreated with 100 nM Pregnenolone monosulfate sodium, the effects of THC were significantly attenuated (15.1 ± 1.8% inhibition). These effects may be due to Pregnenolone monosulfate sodium's presynaptic actions. Thus, Pregnenolone monosulfate sodium prevented the THC-induced increase in paired-pulse ratio but did not alter the amplitude or decay time of miniature EPSCs. [1]
In vivo
Pregnenolone monosulfate sodium (2, 4 mg/kg) injected before each dose reduced WIN 55,212-2 intake and lowered breakpoints in a progressive ratio schedule.
Pregnenolone monosulfate sodium (2-6 mg/kg) blocked THC-induced food intake in Wistar rats and C57BL/6N mice and attenuated THC-induced memory impairment in mice, but it did not modify these behaviors by itself [1].
Alias3β-Hydroxy-5-pregnen-20-one monosulfate sodium
Chemical Properties
Molecular Weight418.52
FormulaC21H31NaO5S
Cas No.1852-38-6
SmilesC[C@@]12[C@]3([H])[C@](CC=C1C[C@H](CC2)OS(=O)([O-])=O)([H])[C@@]4([H])[C@](CC3)([C@H](CC4)C(C)=O)C.[Na+]
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 80.00 mg/mL (191.15 mM), Sonication is recommended.
H2O: 2.00 mg/mL (4.78 mM), Sonication is recommended.
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM2.3894 mL11.9469 mL23.8937 mL119.4686 mL
DMSO
1mg5mg10mg50mg
5 mM0.4779 mL2.3894 mL4.7787 mL23.8937 mL
10 mM0.2389 mL1.1947 mL2.3894 mL11.9469 mL
20 mM0.1195 mL0.5973 mL1.1947 mL5.9734 mL
50 mM0.0478 mL0.2389 mL0.4779 mL2.3894 mL
100 mM0.0239 mL0.1195 mL0.2389 mL1.1947 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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