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Pregnenolone monosulfate

Pregnenolone monosulfate
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Purity:99.46%
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Pregnenolone monosulfate

Catalog No. T12536Cas No. 1247-64-9
Pregnenolone monosulfate (3β-Hydroxy-5-pregnen-20-one monosulfate) is a potent nootropic steroid that positively regulates NMDA recordings and is utilized in the study of neuroticism and depression.
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Pack SizePriceAvailabilityQuantity
5 mg$46In Stock
10 mg$64In Stock
25 mg$126In Stock
1 mL x 10 mM (in DMSO)$53In Stock
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Product Introduction

Bioactivity
Description
Pregnenolone monosulfate (3β-Hydroxy-5-pregnen-20-one monosulfate) is a potent nootropic steroid that positively regulates NMDA recordings and is utilized in the study of neuroticism and depression.
In vitro
Pregnenolone monosulfate, as a signaling-specific negative allosteric modulator, antagonizes most of the known behavioral and in vivo effects of THC. The effect of THC is significantly attenuated when slices are pre-treated with 100 nM Pregnenolone monosulfate (inhibition rate of 15.1±1.8%).
Alias3β-Hydroxy-5-pregnen-20-one monosulfate
Chemical Properties
Molecular Weight396.54
FormulaC21H32O5S
Cas No.1247-64-9
Storage & Solubility Information
Storagestore at low temperature,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 50 mg/mL (126.09 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.5218 mL12.6091 mL25.2181 mL126.0907 mL
5 mM0.5044 mL2.5218 mL5.0436 mL25.2181 mL
10 mM0.2522 mL1.2609 mL2.5218 mL12.6091 mL
20 mM0.1261 mL0.6305 mL1.2609 mL6.3045 mL
50 mM0.0504 mL0.2522 mL0.5044 mL2.5218 mL
100 mM0.0252 mL0.1261 mL0.2522 mL1.2609 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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