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1-Aminocyclopropane-1-carboxylic acid

Catalog No. T4752Cas No. 22059-21-8
Alias ACC, 1-Aminocyclopropanecarboxylic acid, 1-Amino-1-carboxycyclopropane

1-Aminocyclopropane-1-carboxylic acid (ACC) is an intermediate in the synthesis of ethylene, the plant hormone responsible for biological processes ranging from seed germination to organ senescence. It is a small molecule agonist at the glycine modulatory site of the NMDA receptor (EC50 = 0.7-0.9 μM) in the presence of low levels (1 μM) of glutamate and as a competitive antagonist at the glutamate-binding site on NMDA receptors (EC50 = 81.6 nM) with high levels (10 μM) of glutamate.2 This compound has been reported to protect against neuron cell death in vivo models of ischemia by enabling moderate levels of NMDA receptor activation and attenuating any excess NMDA receptor signaling that may lead to neurotoxicity.

1-Aminocyclopropane-1-carboxylic acid

1-Aminocyclopropane-1-carboxylic acid

Purity: 97.91%
Catalog No. T4752Alias ACC, 1-Aminocyclopropanecarboxylic acid, 1-Amino-1-carboxycyclopropaneCas No. 22059-21-8
1-Aminocyclopropane-1-carboxylic acid (ACC) is an intermediate in the synthesis of ethylene, the plant hormone responsible for biological processes ranging from seed germination to organ senescence. It is a small molecule agonist at the glycine modulatory site of the NMDA receptor (EC50 = 0.7-0.9 μM) in the presence of low levels (1 μM) of glutamate and as a competitive antagonist at the glutamate-binding site on NMDA receptors (EC50 = 81.6 nM) with high levels (10 μM) of glutamate.2 This compound has been reported to protect against neuron cell death in vivo models of ischemia by enabling moderate levels of NMDA receptor activation and attenuating any excess NMDA receptor signaling that may lead to neurotoxicity.
Pack SizePriceAvailabilityQuantity
500 mg$46In Stock
1 mL x 10 mM (in H2O)$48In Stock
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Purity:97.91%
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Product Introduction

Bioactivity
Description
1-Aminocyclopropane-1-carboxylic acid (ACC) is an intermediate in the synthesis of ethylene, the plant hormone responsible for biological processes ranging from seed germination to organ senescence. It is a small molecule agonist at the glycine modulatory site of the NMDA receptor (EC50 = 0.7-0.9 μM) in the presence of low levels (1 μM) of glutamate and as a competitive antagonist at the glutamate-binding site on NMDA receptors (EC50 = 81.6 nM) with high levels (10 μM) of glutamate.2 This compound has been reported to protect against neuron cell death in vivo models of ischemia by enabling moderate levels of NMDA receptor activation and attenuating any excess NMDA receptor signaling that may lead to neurotoxicity.
Targets&IC50
NMDAR:0.7-0.9 µM (EC50)
AliasACC, 1-Aminocyclopropanecarboxylic acid, 1-Amino-1-carboxycyclopropane
Chemical Properties
Molecular Weight101.1
FormulaC4H7NO2
Cas No.22059-21-8
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: 10 mM
DMSO: Insoluble
Solution Preparation Table
H2O
1mg5mg10mg50mg
1 mM9.8912 mL49.4560 mL98.9120 mL494.5598 mL
5 mM1.9782 mL9.8912 mL19.7824 mL98.9120 mL
10 mM0.9891 mL4.9456 mL9.8912 mL49.4560 mL

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