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PROTAC Mcl1 degrader-1
🥰Excellent
Catalog No. T11975Cas No. 2163793-38-0
PROTAC Mcl1 degrader-1 is a Cereblon ligand-based targeted chimeric protein degrader (PROTAC), a selective Mcl-1 inhibitor. By hijacking the CRBN ubiquitin ligase to form a ternary complex with the target protein, it induces Mcl-1 ubiquitination. It can be used for cancer research.
PROTAC Mcl1 degrader-1
🥰Excellent
Catalog No. T11975Cas No. 2163793-38-0
PROTAC Mcl1 degrader-1 is a Cereblon ligand-based targeted chimeric protein degrader (PROTAC), a selective Mcl-1 inhibitor. By hijacking the CRBN ubiquitin ligase to form a ternary complex with the target protein, it induces Mcl-1 ubiquitination. It can be used for cancer research.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $455 | In Stock | |
| 5 mg | $1,390 | In Stock | |
| 10 mg | $1,880 | In Stock | |
| 25 mg | $2,790 | In Stock | |
| 50 mg | $3,770 | In Stock |
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | PROTAC Mcl1 degrader-1 is a Cereblon ligand-based targeted chimeric protein degrader (PROTAC), a selective Mcl-1 inhibitor. By hijacking the CRBN ubiquitin ligase to form a ternary complex with the target protein, it induces Mcl-1 ubiquitination. It can be used for cancer research. |
| Targets&IC50 | MCL1:0.78 μM, BCL2:0.54 μM |
| In vitro | PROTAC Mcl1 degrader-1 (Compound C3) induces ubiquitination of Mcl-1 and promotes its proteasomal degradation by binding the Mcl-1 inhibitor S1-6 (with μM range affinity) to the E3 ligase cereblon (CRBN) ligand, pomalidomide.PROTAC Mcl1 degrader-1 selectively targets Mcl-1, a member of the Bcl-2 family, with an IC50 of 078 μM. PROTAC Mcl1 degrader-1 selectively targets Mcl-1 (a member of the Bcl-2 family) with an IC50 of 0.78 μM, and also inhibits Bcl-2 with an IC50 of 0.54 μM. [1] PROTAC Mcl1 degrader-1 (0-10 μM; 0-24 hours) selectively reduces Mcl-1 and Bcl-2 protein levels in HeLa cells by a time- and concentration-dependent mechanism. [1] PROTAC Mcl1 degrader-1 (0-2 μM; 24 hours) exhibits cytotoxic effects on H23 cells. [1] |
| Molecular Weight | 909.84 |
| Formula | C45H45BrN6O8S |
| Cas No. | 2163793-38-0 |
| Smiles | O=C1NC(=O)C(N2C(=O)C=3C=CC=C(NCCCCCCNC(=O)CCCCC(=O)NCCN4C(=O)C5=CC=CC=6C(SC7=CC=C(Br)C=C7)=CC=C(C4=O)C56)C3C2=O)CC1 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 40 mg/mL (43.96 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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