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PROTAC IDO1 Degrader-1
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Catalog No. T37329Cas No. 2488851-89-2
Alias PROTAC IDO1 Degrader-1
PROTAC IDO1 Degrader-1, a pioneering compound, efficiently targets indoleamine 2,3-dioxygenase 1 (IDO1) for ubiquitination and degradation by recruiting IDO1 to the CRBN E3 ligase, thereby facilitating its entry into the ubiquitin-proteasome system (UPS) with a DC50 of 2.84 μM. This compound also moderately enhances the tumor-killing efficacy of HER2 CAR-T cells[1].
PROTAC IDO1 Degrader-1
😃Good
Catalog No. T37329Alias PROTAC IDO1 Degrader-1Cas No. 2488851-89-2
PROTAC IDO1 Degrader-1, a pioneering compound, efficiently targets indoleamine 2,3-dioxygenase 1 (IDO1) for ubiquitination and degradation by recruiting IDO1 to the CRBN E3 ligase, thereby facilitating its entry into the ubiquitin-proteasome system (UPS) with a DC50 of 2.84 μM. This compound also moderately enhances the tumor-killing efficacy of HER2 CAR-T cells[1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $697 | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | PROTAC IDO1 Degrader-1, a pioneering compound, efficiently targets indoleamine 2,3-dioxygenase 1 (IDO1) for ubiquitination and degradation by recruiting IDO1 to the CRBN E3 ligase, thereby facilitating its entry into the ubiquitin-proteasome system (UPS) with a DC50 of 2.84 μM. This compound also moderately enhances the tumor-killing efficacy of HER2 CAR-T cells[1]. |
| Targets&IC50 | IDO1:1.07 μM (IC50), IDO1:2.84 μM (DC50) |
| In vitro | PROTAC IDO1 Degrader-1 (compound 2c) (10 μM; 24 hours) notably decreases IDO1 levels induced by IFN-γ [1]. When combined with IFN-γ (5 ng/mL) and incubated with HeLa cells for 24 hours, significant dose-dependent degradation is observed. PROTAC IDO1 Degrader-1, in combination with chimeric antigen receptor-modified T (CAR-T) cells, enhances the tumor-killing activity of HER-2 CAR-T cells [1]. It induces significant and persistent degradation of IDO1 with a maximum degradation (dmax) of 93% in HeLa cells [1]. |
| Alias | PROTAC IDO1 Degrader-1 |
| Molecular Weight | 966.816 |
| Formula | C40H53BrFN9O13 |
| Cas No. | 2488851-89-2 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
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