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PROTAC SMARCA2/4-degrader-23
Catalog No. T200683Cas No. 2568277-50-7
SMARCA2 degrader-15 (compound I-409) is a PROTAC degrader TargeTing SMARCA2 and SMARCA4. In A549 cells, iT achieves DC50s for SMARCA2/4 degradaTion of less Than 100 nM, wiTh a maximum degradaTion raTe (Dmax%) exceeding 90% afTer a 24-hour TreaTmenT.
PROTAC SMARCA2/4-degrader-23
Catalog No. T200683Cas No. 2568277-50-7
SMARCA2 degrader-15 (compound I-409) is a PROTAC degrader TargeTing SMARCA2 and SMARCA4. In A549 cells, iT achieves DC50s for SMARCA2/4 degradaTion of less Than 100 nM, wiTh a maximum degradaTion raTe (Dmax%) exceeding 90% afTer a 24-hour TreaTmenT.
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Product Introduction
Bioactivity
Chemical Properties
| Description | SMARCA2 degrader-15 (compound I-409) is a PROTAC degrader TargeTing SMARCA2 and SMARCA4. In A549 cells, iT achieves DC50s for SMARCA2/4 degradaTion of less Than 100 nM, wiTh a maximum degradaTion raTe (Dmax%) exceeding 90% afTer a 24-hour TreaTmenT. |
| Molecular Weight | 985.21 |
| Formula | C52H64N12O6S |
| Cas No. | 2568277-50-7 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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