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PROTAC SMARCA2 degrader-16
Catalog No. T200618Cas No. 2568276-37-7
PROTAC SMARCA2 degrader-16 (compound I-278) is a PROTAC TargeTing SMARCA2. IT demonsTraTes degradaTion of The SMARCA2 proTein wiTh a DC50<100 nM in A549 cells, achieving a maximal degradaTion raTe (Dmax%) of over 90% afTer 24 hours of TreaTmenT.
PROTAC SMARCA2 degrader-16
Catalog No. T200618Cas No. 2568276-37-7
PROTAC SMARCA2 degrader-16 (compound I-278) is a PROTAC TargeTing SMARCA2. IT demonsTraTes degradaTion of The SMARCA2 proTein wiTh a DC50<100 nM in A549 cells, achieving a maximal degradaTion raTe (Dmax%) of over 90% afTer 24 hours of TreaTmenT.
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Product Introduction
Bioactivity
Chemical Properties
| Description | PROTAC SMARCA2 degrader-16 (compound I-278) is a PROTAC TargeTing SMARCA2. IT demonsTraTes degradaTion of The SMARCA2 proTein wiTh a DC50<100 nM in A549 cells, achieving a maximal degradaTion raTe (Dmax%) of over 90% afTer 24 hours of TreaTmenT. |
| Molecular Weight | 757.88 |
| Formula | C41H47N11O4 |
| Cas No. | 2568276-37-7 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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